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兔耳的交感神经血管舒张

Sympathetic vasodilatation in the rabbit ear.

作者信息

HOLTON P, RAND M J

出版信息

Br J Pharmacol Chemother. 1962 Dec;19(3):513-26. doi: 10.1111/j.1476-5381.1962.tb01457.x.

DOI:10.1111/j.1476-5381.1962.tb01457.x
PMID:13961468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1482209/
Abstract

Changes in the blood content of a 1 cm(2) portion of the intact rabbit's ear were studied with transillumination and a photocell. Stimulation of the post-ganglionic sympathetic nerves produced a decrease in blood content, attributable to vasoconstriction, followed by an increased blood content, attributable to vasodilatation. The vasodilatation was enhanced by eserine and decreased by atropine. Guanethidine abolished the vasoconstriction but not the vasodilatation. After the ganglion had been decentralized by degeneration of the pre-ganglionic sympathetic nerves the vessels had an increased sensitivity to acetylcholine and the vasodilatation in response to sympathetic stimulation was enhanced. It is concluded that sympathetic stimulation results in the liberation of acetylcholine which causes vasodilatation.

摘要

采用透照法和光电管研究了完整兔耳1平方厘米部分的血液含量变化。刺激节后交感神经会导致血液含量降低，这归因于血管收缩，随后血液含量增加，这归因于血管舒张。毒扁豆碱可增强血管舒张，阿托品则使其减弱。胍乙啶消除了血管收缩，但未消除血管舒张。在节前交感神经变性使神经节去神经支配后，血管对乙酰胆碱的敏感性增加，对交感神经刺激的血管舒张反应增强。得出的结论是，交感神经刺激导致乙酰胆碱释放，从而引起血管舒张。

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