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The vessels of the isolated rabbit ear were perfused at 23 mbar with Krebs solution with (tonic) and without (atonic) noradrenaline (5.9 x 10(-7)M) at selected temperatures of 20 degrees -38 degrees C. Peripheral resistance units (PRU) were calculated from the observed peak flow rates and alterations caused by drugs expressed as Delta% PRU.2. ACh is constrictor in the atonic vessel.3. ACh is a vasodilator of the tonic vessel perfused with NA. This effect is potentiated by anticholinesterase and by denervation, unaffected by botulinum toxin and antagonized by atropine. ACh also dilates the vessel perfused with vasopressin.4. Increasing the temperature reduces the responses to ACh but increases the effect of anticholinesterase.5. Nicotine causes a dose dependent dilatation of the tonic vessels, reduced but not abolished by C(6), by atropine, by botulinum toxin and by denervation.6. Nicotine causes a dose dependent constriction of the atonic vessels, abolished by C(6) and by phentolamine, reduced by denervation, but unaffected by botulinum toxin.

将分离出的兔耳血管在23毫巴下，于20℃至38℃的选定温度下，用含（张力性）和不含（无张力性）去甲肾上腺素（5.9×10⁻⁷M）的 Krebs 溶液进行灌注。根据观察到的峰值流速计算外周阻力单位（PRU），并将药物引起的变化表示为Δ%PRU。
乙酰胆碱（ACh）在无张力性血管中起收缩作用。
ACh 是灌注了去甲肾上腺素的张力性血管的血管扩张剂。这种作用被抗胆碱酯酶和去神经作用增强，不受肉毒杆菌毒素影响，并被阿托品拮抗。ACh 也能使灌注了血管加压素的血管扩张。
升高温度会降低对 ACh 的反应，但会增强抗胆碱酯酶的作用。
尼古丁会引起张力性血管剂量依赖性扩张，被C₆、阿托品、肉毒杆菌毒素和去神经作用减弱但未消除。
尼古丁会引起无张力性血管剂量依赖性收缩，被C₆和酚妥拉明消除，被去神经作用减弱，但不受肉毒杆菌毒素影响。

The vessels of the isolated rabbit ear were perfused at 23 mbar with Krebs solution with (tonic) and without (atonic) noradrenaline (5.9 x 10(-7)M) at selected temperatures of 20 degrees -38 degrees C. Peripheral resistance units (PRU) were calculated from the observed peak flow rates and alterations caused by drugs expressed as Delta% PRU.2. ACh is constrictor in the atonic vessel.3. ACh is a vasodilator of the tonic vessel perfused with NA. This effect is potentiated by anticholinesterase and by denervation, unaffected by botulinum toxin and antagonized by atropine. ACh also dilates the vessel perfused with vasopressin.4. Increasing the temperature reduces the responses to ACh but increases the effect of anticholinesterase.5. Nicotine causes a dose dependent dilatation of the tonic vessels, reduced but not abolished by C(6), by atropine, by botulinum toxin and by denervation.6. Nicotine causes a dose dependent constriction of the atonic vessels, abolished by C(6) and by phentolamine, reduced by denervation, but unaffected by botulinum toxin.

将分离出的兔耳血管在23毫巴下，于20℃至38℃的选定温度下，用含（张力性）和不含（无张力性）去甲肾上腺素（5.9×10⁻⁷M）的 Krebs 溶液进行灌注。根据观察到的峰值流速计算外周阻力单位（PRU），并将药物引起的变化表示为Δ%PRU。
乙酰胆碱（ACh）在无张力性血管中起收缩作用。
ACh 是灌注了去甲肾上腺素的张力性血管的血管扩张剂。这种作用被抗胆碱酯酶和去神经作用增强，不受肉毒杆菌毒素影响，并被阿托品拮抗。ACh 也能使灌注了血管加压素的血管扩张。
升高温度会降低对 ACh 的反应，但会增强抗胆碱酯酶的作用。
尼古丁会引起张力性血管剂量依赖性扩张，被C₆、阿托品、肉毒杆菌毒素和去神经作用减弱但未消除。
尼古丁会引起无张力性血管剂量依赖性收缩，被C₆和酚妥拉明消除，被去神经作用减弱，但不受肉毒杆菌毒素影响。

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