兔耳灌注血管对乙酰胆碱和尼古丁的反应。
Response to acetylcholine and nicotine of the perfused vessels of the rabbit ear.
作者信息
Graham J D, Suhaila A, Tai A
出版信息
Br J Pharmacol. 1971 Mar;41(3):500-6. doi: 10.1111/j.1476-5381.1971.tb08047.x.
Abstract
- The vessels of the isolated rabbit ear were perfused at 23 mbar with Krebs solution with (tonic) and without (atonic) noradrenaline (5.9 x 10(-7)M) at selected temperatures of 20 degrees -38 degrees C. Peripheral resistance units (PRU) were calculated from the observed peak flow rates and alterations caused by drugs expressed as Delta% PRU.2. ACh is constrictor in the atonic vessel.3. ACh is a vasodilator of the tonic vessel perfused with NA. This effect is potentiated by anticholinesterase and by denervation, unaffected by botulinum toxin and antagonized by atropine. ACh also dilates the vessel perfused with vasopressin.4. Increasing the temperature reduces the responses to ACh but increases the effect of anticholinesterase.5. Nicotine causes a dose dependent dilatation of the tonic vessels, reduced but not abolished by C(6), by atropine, by botulinum toxin and by denervation.6. Nicotine causes a dose dependent constriction of the atonic vessels, abolished by C(6) and by phentolamine, reduced by denervation, but unaffected by botulinum toxin.
摘要
将分离出的兔耳血管在23毫巴下，于20℃至38℃的选定温度下，用含（张力性）和不含（无张力性）去甲肾上腺素（5.9×10⁻⁷M）的 Krebs 溶液进行灌注。根据观察到的峰值流速计算外周阻力单位（PRU），并将药物引起的变化表示为Δ%PRU。
乙酰胆碱（ACh）在无张力性血管中起收缩作用。
ACh 是灌注了去甲肾上腺素的张力性血管的血管扩张剂。这种作用被抗胆碱酯酶和去神经作用增强，不受肉毒杆菌毒素影响，并被阿托品拮抗。ACh 也能使灌注了血管加压素的血管扩张。
升高温度会降低对 ACh 的反应，但会增强抗胆碱酯酶的作用。
尼古丁会引起张力性血管剂量依赖性扩张，被C₆、阿托品、肉毒杆菌毒素和去神经作用减弱但未消除。
尼古丁会引起无张力性血管剂量依赖性收缩，被C₆和酚妥拉明消除，被去神经作用减弱，但不受肉毒杆菌毒素影响。
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The actions of prostaglandins E 1 and F 2 on the on the perfused vessels of the isolated rabbit ear.前列腺素E1和F2对离体兔耳灌注血管的作用。
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本文引用的文献
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Reversal of the vascular response to acetylcholine and adrenaline.对乙酰胆碱和肾上腺素血管反应的逆转。
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Sympathetic vasodilatation in the rabbit ear.兔耳的交感神经血管舒张
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Cholinesterase and the nerve supply to blood vessels in the rabbit's external ear.胆碱酯酶与家兔外耳血管的神经支配
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The effects of nicotine on the blood vessels of skeletal muscle in the cat; an investigation of vasomotor axon reflexes.尼古丁对猫骨骼肌血管的影响；血管运动轴突反射的研究
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An explanation for the heightened vascular reactivity of the denervated rabbit's ear.去神经支配兔耳血管反应性增强的一种解释。
J Physiol. 1953 Sep;121(3):603-22. doi: 10.1113/jphysiol.1953.sp004968.
8
The artery of the denervated rabbit's ear as a sensitive pharmacological test object.去神经支配兔耳动脉作为一种敏感的药理学测试对象。
J Physiol. 1953 Sep;121(3):593-602. doi: 10.1113/jphysiol.1953.sp004967.
9
Nicotine-like actions in auricles and blood vessels after denervation.去神经后耳廓和血管中的尼古丁样作用。
Br J Pharmacol Chemother. 1953 Sep;8(3):348-51. doi: 10.1111/j.1476-5381.1953.tb00805.x.
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The action of nicotine and acetylcholine on the vessels of the rabbit's ear.尼古丁和乙酰胆碱对兔耳血管的作用。
Br J Pharmacol Chemother. 1953 Jun;8(2):156-61. doi: 10.1111/j.1476-5381.1953.tb00770.x.
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