色胺诱导小鼠产生高胰高血糖素血症：外周5-羟色胺2型受体的作用
Hyperglucagonemia induced in mice by tryptamine: involvement of the peripheral 5-HT2 receptors.
作者信息
Yamada J, Sugimoto Y, Kimura I, Watanabe Y, Takeuchi N, Horisaka K
机构信息
Department of Pharmacology, Kobe Women's College of Pharmacy, Japan.
出版信息
Eur J Pharmacol. 1992 Jun 5;216(2):307-10. doi: 10.1016/0014-2999(92)90375-e.
The effects of an indoleamine, tryptamine, on plasma glucagon levels were investigated in mice. Tryptamine induced dose-related increases in plasma glucagon levels. The hyperglucagonemia effects of tryptamine were completely antagonized by methysergide and ketanserin which have a high affinity to 5-HT2 receptors. In addition, the peripheral 5-HT2 receptor antagonist, xylamidine, also strongly inhibited tryptamine-induced hyperglucagonemia. Our results indicate that the peripheral 5-HT2 receptors mediate the increase in plasma glucagon levels induced by tryptamine and that these receptors may have a role in the control of glucagon secretion.
在小鼠中研究了一种吲哚胺——色胺对血浆胰高血糖素水平的影响。色胺可引起血浆胰高血糖素水平呈剂量相关的升高。色胺引起的高胰高血糖素血症效应被对5-HT2受体具有高亲和力的麦角新碱和酮色林完全拮抗。此外，外周5-HT2受体拮抗剂二甲苯丙胺也强烈抑制色胺诱导的高胰高血糖素血症。我们的结果表明，外周5-HT2受体介导色胺诱导的血浆胰高血糖素水平升高，并且这些受体可能在胰高血糖素分泌的控制中发挥作用。
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