色胺对小鼠的降血糖作用：通过5-羟色胺受体介导

The hypoglycemic effects of tryptamine in mice: mediation by 5-HT receptors.

作者信息

Yamada J, Sugimoto Y, Kimura I, Takeuchi N, Horisaka K

机构信息

Department of Pharmacology, Kobe Women's College of Pharmacy, Japan.

出版信息

Eur J Pharmacol. 1988 Nov 1;156(2):299-301. doi: 10.1016/0014-2999(88)90338-x.

DOI:10.1016/0014-2999(88)90338-x

PMID:3240774

Abstract

The effects of tryptamine on blood glucose levels were studied. Tryptamine induced significant hypoglycemia in mice. The hypoglycemia elicited by tryptamine was strongly antagonized by methysergide, an antagonist of both 5-HT1 and 5-HT2 receptors. A 5-HT2 receptor antagonist, ketanserin, partially inhibited the tryptamine-induced hypoglycemia. These results suggest that tryptamine-induced hypoglycemia is mediated by 5-HT1 and 5-HT2 receptors.

摘要

研究了色胺对血糖水平的影响。色胺可诱导小鼠出现显著低血糖。色胺引发的低血糖被5-HT1和5-HT2受体拮抗剂美西麦角强烈拮抗。5-HT2受体拮抗剂酮色林部分抑制了色胺诱导的低血糖。这些结果表明，色胺诱导的低血糖是由5-HT1和5-HT2受体介导的。