Sánchez-Pozo A, Arenas C, Sánchez-Medina F
Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Granada, Spain.
Eur J Pharmacol. 1992 May 1;228(1):29-35. doi: 10.1016/0926-6917(92)90008-z.
The administration of a 4 mg/kg dose of dipyridamole daily in chickens fed a diet supplemented with 2% cholesterol reversed the hypercholesterolemic effects of the diet. In particular, it reduced the plasma cholesterol concentration in approximately 18%; the levels of very-low-density lipoproteins and intermediate-density lipoproteins and the liver cholesterol content. Although the mechanism was not fully elucidated, the increased excretion of cholesterol seemed to be responsible for the lipid lowering effect. When dipyridamole was administered in chickens fed the same diet without cholesterol no significant changes were observed. Inasmuch as the chicken lipoprotein metabolism differs in several aspects to human, the extrapolation of the hypocholesterolemic effect of dipyridamole to man must be made with care.
给每日喂食添加2%胆固醇日粮的鸡每日服用4毫克/千克剂量的双嘧达莫，可逆转该日粮的高胆固醇血症效应。具体而言，它使血浆胆固醇浓度降低了约18%；极低密度脂蛋白和中间密度脂蛋白水平以及肝脏胆固醇含量也有所降低。尽管其机制尚未完全阐明，但胆固醇排泄增加似乎是脂质降低效应的原因。当给喂食相同无胆固醇日粮的鸡服用双嘧达莫时，未观察到显著变化。鉴于鸡的脂蛋白代谢在几个方面与人类不同，将双嘧达莫的降胆固醇效应外推至人类时必须谨慎。
