• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Facilitation of neuromuscular transmission by anticholinesterase drugs.抗胆碱酯酶药物对神经肌肉传递的促进作用。
Br J Pharmacol Chemother. 1963 Feb;20(1):63-73. doi: 10.1111/j.1476-5381.1963.tb01297.x.
2
THE ANTI-TUBOCURARINE EFFECTS OF PHYSOSTIGMINE, NEOSTIGMINE, AND EDROPHONIUM IN THE RAT.毒扁豆碱、新斯的明和依酚氯铵对大鼠的抗筒箭毒碱作用
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1964 May 25;248:195-203.
3
ACTIONS OF HEMICHOLINIUM (HC-3) ON NEUROMUSCULAR TRANSMISSION.半箭毒碱（HC - 3）对神经肌肉传递的作用
Br J Pharmacol Chemother. 1964 Jun;22(3):441-52. doi: 10.1111/j.1476-5381.1964.tb01699.x.
4
Studies on the repetitive discharges evoked in motor nerve and skeletal muscle after injection of anticholinesterase drugs.注射抗胆碱酯酶药物后运动神经和骨骼肌中诱发的重复放电的研究。
Br J Pharmacol Chemother. 1963 Apr;20(2):326-44. doi: 10.1111/j.1476-5381.1963.tb01472.x.
5
Sepsis attenuates the intensity of the neuromuscular blocking effect of d-tubocurarine and the antagonistic actions of neostigmine and edrophonium accompanying depression of muscle contractility of the diaphragm.脓毒症会减弱d -筒箭毒碱的神经肌肉阻滞作用强度以及新斯的明和依酚氯铵的拮抗作用，同时伴有膈肌肌肉收缩力的降低。
Acta Anaesthesiol Scand. 1999 Feb;43(2):196-201. doi: 10.1034/j.1399-6576.1999.430213.x.
6
Neostigmine but not edrophonium prolongs the action of mivacurium.新斯的明而非依酚氯铵可延长米库氯铵的作用时间。
Can J Anaesth. 1996 Dec;43(12):1220-3. doi: 10.1007/BF03013428.
7
The relationship between the pharmacokinetics, cholinesterase inhibition and facilitation of twitch tension of the quaternary ammonium anticholinesterase drugs, neostigmine, pyridostigmine, edrophonium and 3-hydroxyphenyltrimethylammonium.季铵类抗胆碱酯酶药物新斯的明、吡啶斯的明、依酚氯铵和3-羟基苯基三甲基铵的药代动力学、胆碱酯酶抑制作用与抽搐张力增强之间的关系。
Br J Pharmacol. 1979 Aug;66(4):525-30. doi: 10.1111/j.1476-5381.1979.tb13690.x.
8
The interaction between edrophonium (tensilon) and acetylcholine at the motor end-plate.依酚氯铵（腾喜龙）与乙酰胆碱在运动终板处的相互作用。
Br J Pharmacol Chemother. 1957 Jun;12(2):260-4. doi: 10.1111/j.1476-5381.1957.tb00131.x.
9
[MYASTHENIA GRAVIS WITH FOCAL INFILTRATION OF THE END PLATE ZONE].[伴有终板区局灶性浸润的重症肌无力]
Acta Neuropathol. 1963 Feb 11;3:246-52. doi: 10.1007/BF00686418.
10
The neuromuscular blocking action of benzoquinonium chloride in the cat and in the hen.氯化苄醌铵在猫和母鸡体内的神经肌肉阻断作用。
Br J Pharmacol Chemother. 1958 Dec;13(4):521-30. doi: 10.1111/j.1476-5381.1958.tb00247.x.

引用本文的文献

1
THE EFFECTS OF PHYSOSTIGMINE ON THE MECHANICAL AND ELECTRICAL RESPONSES OF THE CAT NICTATING MEMBRANE.毒扁豆碱对猫瞬膜机械和电反应的影响。
Br J Pharmacol Chemother. 1964 Jun;22(3):558-76. doi: 10.1111/j.1476-5381.1964.tb01710.x.

本文引用的文献

1
Reactions of avian muscle to acetylcholine and eserine.禽类肌肉对乙酰胆碱和毒扁豆碱的反应。
J Physiol. 1938 Oct 14;94(1):101-17. doi: 10.1113/jphysiol.1938.sp003665.
2
The action of eserine-like and curare-like substances on the responses of frog's nerve-muscle preparations to repetitive stimulation.毒扁豆碱样和箭毒样物质对青蛙神经肌肉标本对重复刺激反应的作用。
J Physiol. 1938 Aug 15;93(3):215-62. doi: 10.1113/jphysiol.1938.sp003637.
3
The actions of acetylcholine on denervated mammalian and frog's muscle.乙酰胆碱对去神经支配的哺乳动物和青蛙肌肉的作用。
J Physiol. 1937 Jun 3;89(4):438-61. doi: 10.1113/jphysiol.1937.sp003491.
4
Action potentials of normal mammalian muscle. Effects of acetylcholine and eserine.正常哺乳动物肌肉的动作电位。乙酰胆碱和毒扁豆碱的作用。
J Physiol. 1937 Mar 5;89(2):220-37. doi: 10.1113/jphysiol.1937.sp003474.
5
Reactions of the normal mammalian muscle to acetylcholine and to eserine.正常哺乳动物肌肉对乙酰胆碱和毒扁豆碱的反应。
J Physiol. 1936 Sep 8;87(4):394-424. doi: 10.1113/jphysiol.1936.sp003414.
6
Pharmacological properties of some neostigmine analogs.某些新斯的明类似物的药理学特性。
J Pharmacol Exp Ther. 1950 May;99(1):16-32.
7
Studies on the interrelationship of certain cholinergic compounds; the pharmacology of 3-acetoxy phenyltrimethylammonium methylsulfate.
J Pharmacol Exp Ther. 1949 Oct;97(2):190-207.
8
Mode of action of antagonists to curare.箭毒拮抗剂的作用方式。
J Pharmacol Exp Ther. 1952 Aug;105(4):391-9.
9
The mechanism of anticurare action of certain neostigmine analogues.某些新斯的明类似物的抗箭毒作用机制。
Br J Pharmacol Chemother. 1952 Jun;7(2):223-36. doi: 10.1111/j.1476-5381.1952.tb01317.x.
10
The pharmacology of anti-curare agents.抗箭毒剂的药理学。
Ann N Y Acad Sci. 1951 Oct;54(3):438-59. doi: 10.1111/j.1749-6632.1951.tb39935.x.

抗胆碱酯酶药物对神经肌肉传递的促进作用。

Facilitation of neuromuscular transmission by anticholinesterase drugs.

作者信息

BLABER L C

出版信息

Br J Pharmacol Chemother. 1963 Feb;20(1):63-73. doi: 10.1111/j.1476-5381.1963.tb01297.x.

DOI:10.1111/j.1476-5381.1963.tb01297.x
PMID:13971349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1703737/
Abstract

A close correlation has been shown to exist between the in vitro anticholinesterase potencies of ambenonium, neostigmine, methoxyambenonium and edrophonium chloride and their abilities to increase muscle contractions produced by close-arterial injections of acetylcholine. No correlation was found between the anticholinesterase potencies of the drugs and their potentiations of the maximal twitch in response to electrical stimulation, or their antagonisms of tubocurarine. It is concluded that some action, in addition to inhibition of cholinesterase, contributed to their facilitation at the neuromuscular junction, and it is suggested that this action may be at the prejunctional site.

摘要

已表明安贝氯铵、新斯的明、甲氧基安贝氯铵和氯化依酚氯铵的体外抗胆碱酯酶效力与其通过动脉旁注射乙酰胆碱增强肌肉收缩的能力之间存在密切相关性。未发现这些药物的抗胆碱酯酶效力与其对电刺激最大抽搐的增强作用或对筒箭毒碱的拮抗作用之间存在相关性。得出的结论是，除抑制胆碱酯酶外，某些作用有助于它们在神经肌肉接头处的易化作用，并且表明这种作用可能发生在神经节前部位。