抗胆碱酯酶药物对神经肌肉传递的促进作用。

Facilitation of neuromuscular transmission by anticholinesterase drugs.

作者信息

BLABER L C

出版信息

Br J Pharmacol Chemother. 1963 Feb;20(1):63-73. doi: 10.1111/j.1476-5381.1963.tb01297.x.

DOI:10.1111/j.1476-5381.1963.tb01297.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1703737/

Abstract

A close correlation has been shown to exist between the in vitro anticholinesterase potencies of ambenonium, neostigmine, methoxyambenonium and edrophonium chloride and their abilities to increase muscle contractions produced by close-arterial injections of acetylcholine. No correlation was found between the anticholinesterase potencies of the drugs and their potentiations of the maximal twitch in response to electrical stimulation, or their antagonisms of tubocurarine. It is concluded that some action, in addition to inhibition of cholinesterase, contributed to their facilitation at the neuromuscular junction, and it is suggested that this action may be at the prejunctional site.

摘要

已表明安贝氯铵、新斯的明、甲氧基安贝氯铵和氯化依酚氯铵的体外抗胆碱酯酶效力与其通过动脉旁注射乙酰胆碱增强肌肉收缩的能力之间存在密切相关性。未发现这些药物的抗胆碱酯酶效力与其对电刺激最大抽搐的增强作用或对筒箭毒碱的拮抗作用之间存在相关性。得出的结论是，除抑制胆碱酯酶外，某些作用有助于它们在神经肌肉接头处的易化作用，并且表明这种作用可能发生在神经节前部位。

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