BOWMAN W C
Br J Pharmacol Chemother. 1958 Dec;13(4):521-30. doi: 10.1111/j.1476-5381.1958.tb00247.x.
Benzoquinonium (Mytolon) has been shown to produce a curare-like rather than a decamethonium-like paralysis of neuromuscular transmission in the tibialis anterior and soleus muscle of cats and the gastrocnemius muscle of hens. In the cat, but not in the hen, benzoquinonium had an additional action in preventing both the twitch potentiating action and the anti-curare action of edrophonium, neostigmine, eserine, and tetraethyl pyrophosphate. Paralysis produced by benzoquinonium was antagonized by injected acetylcholine and by acetylcholine liberated by tetanic stimulation of the motor nerve but, in the cat, anticholinesterases were without effect even when they were first administered in circumstances in which acetylcholine accumulation might be expected to occur. These findings suggested that inhibition of cholinesterase played little part in the skeletal muscle effects of the anticholinesterases studied. Although anticholinesterases did not antagonize benzoquinonium paralysis in the cat, they nevertheless potentiated the antagonistic action of injected acetylcholine.
已证实，苯佐铵（米托隆）在猫的胫前肌和比目鱼肌以及母鸡的腓肠肌中，产生的是箭毒样而非十烃季铵样的神经肌肉传递麻痹。在猫中，而非在母鸡中，苯佐铵还有另外一种作用，即能阻止依酚氯铵、新斯的明、毒扁豆碱和焦磷酸四乙酯的抽搐增强作用和抗箭毒作用。苯佐铵引起的麻痹可被注入的乙酰胆碱以及运动神经强直刺激释放的乙酰胆碱所拮抗，但在猫中，抗胆碱酯酶即使在首次给药时处于可能预期乙酰胆碱会蓄积的情况下也没有效果。这些发现表明，在所研究的抗胆碱酯酶的骨骼肌效应中，胆碱酯酶的抑制作用很小。虽然抗胆碱酯酶在猫中不能拮抗苯佐铵引起的麻痹，但它们却能增强注入的乙酰胆碱的拮抗作用。
