Seuri M, Granfors K
Department of Community Health and General Practice, University of Kuopio, Finland.
Eur J Epidemiol. 1992 Jul;8(4):532-8. doi: 10.1007/BF00146372.
Increased risk of high Yersinia enterocolitica 0:3 and 0:9 antibody content has been previously reported in occupations with swine contact. In this study several possible confounders of this elevated risk among pig farmers and abattoir workers were considered. Only in three instances the standardized risk ratio was decreased close to unity, namely after the standardization of Y. enterocolitica 0:3 IgG antibody positivity for age among abattoir workers, after the standardization of Y. enterocolitica 0:9 IgG antibody positivity for farm butchering among pig farmers and for smoking among abattoir workers. As the decrease did not apply for both pig farmers and abattoir workers and for both 0:3 and 0:9 serotypes considered, it seems reasonable to assume that the three decreases represent products of multiple testing inherent in this kind of search of confounders rather than any true effects. In view of the present knowledge on the determinants of yersinia antibodies in populations, the crude risk ratios for elevated yersinia antibodies can be held to be reasonably unconfounded.
先前有报道称，从事与猪接触工作的人群中，小肠结肠炎耶尔森菌0:3和0:9抗体含量升高的风险增加。在本研究中，考虑了养猪户和屠宰场工人中这种风险升高的几个可能的混杂因素。仅在三种情况下，标准化风险比降低至接近1，即在屠宰场工人中对小肠结肠炎耶尔森菌0:3 IgG抗体阳性率进行年龄标准化后、在养猪户中对农场屠宰进行小肠结肠炎耶尔森菌0:9 IgG抗体阳性率标准化后以及在屠宰场工人中对吸烟进行标准化后。由于这种降低并非同时适用于养猪户和屠宰场工人以及所考虑的0:3和0:9两种血清型，似乎有理由认为这三种降低是这种混杂因素搜索中固有的多重检验的结果，而非任何真实效应。鉴于目前关于人群中耶尔森菌抗体决定因素的知识，小肠结肠炎耶尔森菌抗体升高的粗风险比可被认为是合理无混杂的。
