Shepard N T, Webster J C, Baumen M, Schuck P
Vestibular Testing Center, Department of Otolaryngology and Head and Neck Surgery, University of Michigan, Ann Arbor.
Ear Hear. 1992 Jun;13(3):173-80. doi: 10.1097/00003446-199206000-00006.
Auditory brain stem response (ABR) testing is widely used to detect lesions of the auditory neural pathways. The ABR waves depend not only on the integrity of the neural pathways, but also on the condition of the cochlea. To properly interpret the ABR response, it is necessary to understand the effects of cochlear hearing loss on the ABR wave latencies. We studied two populations of subjects with cochlear hearing loss: one with varying degrees of high-frequency hearing loss and the other with varying degrees of flat configuration hearing loss. The degree of cochlear hearing loss was quantified in several different ways and subjected to one linear and three nonlinear regression analyses to test for accuracy in predicting ABR wave latencies and interpeak intervals (waves I, III, V, I-V, I-III, and III-V) for three click intensities. Hearing loss levels from 2 to 6 kHz, in particular 4 kHz, were superior to other audiometric test frequencies as predictors of ABR wave latencies for the group with the high-frequency losses. No particular characterization was found to be superior for the flat hearing loss configurations. From these results, modeled predictions of wave latencies as a function of degree and configuration of hearing loss were made. The modeled predictions are then used to suggest guidelines for interpretations of ABR results where hearing impaired patients are involved.
听性脑干反应（ABR）测试被广泛用于检测听觉神经通路的病变。ABR波不仅取决于神经通路的完整性，还取决于耳蜗的状况。为了正确解读ABR反应，有必要了解耳蜗性听力损失对ABR波潜伏期的影响。我们研究了两组患有耳蜗性听力损失的受试者：一组患有不同程度的高频听力损失，另一组患有不同程度的平坦型听力损失。通过几种不同的方式对耳蜗性听力损失的程度进行量化，并进行一次线性回归分析和三次非线性回归分析，以测试预测三种短声强度下ABR波潜伏期和峰间期（波I、III、V、I-V、I-III和III-V）的准确性。对于高频听力损失组，2至6kHz、特别是4kHz的听力损失水平作为ABR波潜伏期的预测指标优于其他听力测试频率。对于平坦型听力损失类型，未发现有特别优越的特征描述。根据这些结果，建立了波潜伏期作为听力损失程度和类型函数的模型预测。然后，这些模型预测被用于为涉及听力受损患者的ABR结果解读提供指导原则。
