Schmidt W, Villena-Heinsen C, Schmid H, Engel K, Jochum N, Müller A
Universitäts-Frauenklinik mit Poliklinik und Hebammenlehranstalt Homburg/Saar.
Geburtshilfe Frauenheilkd. 1992 Aug;52(8):462-6. doi: 10.1055/s-2007-1023789.
At the University Hospitals of Heidelberg (1970-1988) and Homburg/Saar (1988-1990), 182 patients with vulvar carcinoma were treated. 51 patients had a recurrence of vulvar carcinoma and 21 patients showed a persistence of this tumour. 19 women had a second recurrence of vulvar disease. In these cases, therapy ranged from local surgery to exenteration, depending on the site and tumour extension. 18 patients underwent successful reconstructive surgery. Prognosis was better in cases with local recurrence in comparison to distant sites of metastatic progression (i.e. inguinal nodes or disseminated disease) (p less than 0.001). The five-year survival (after diagnosis of recurrent disease) for patients with early onset of recurrence (less than 20 months after initial therapy) was 28% compared to 68% for patients with late onset of recurrent disease (p less than 0.01).
在海德堡大学医院（1970 - 1988年）和洪堡/萨尔（1988 - 1990年），共治疗了182例外阴癌患者。51例患者出现外阴癌复发，21例患者肿瘤持续存在。19名女性出现外阴疾病二次复发。在这些病例中，根据肿瘤部位和扩展情况，治疗方法从局部手术到盆腔脏器清除术不等。18例患者接受了成功的重建手术。与远处转移进展部位（即腹股沟淋巴结或播散性疾病）相比，局部复发患者的预后更好（p < 0.001）。复发早发（初始治疗后不到20个月）患者的五年生存率（复发疾病诊断后）为28%，而复发晚发患者为68%（p < 0.；01）。
