低温对戊巴比妥钠和氨基甲酸乙酯麻醉大鼠血液酸碱状态及血气的不同影响。

Differential effects of hypothermia upon blood acid-base state and blood gases in sodium pentobarbital and urethane anaesthetised rats.

Alfaro V, Palacios L

Departamento de Bioquímica y Fisiología, Facultad de Biología, Universidad de Barcelona, Spain.

Gen Pharmacol. 1992 Jul;23(4):677-82. doi: 10.1016/0306-3623(92)90147-c.

Abstract

The effects of two anaesthetics, sodium pentobarbital and urethane, and the effects of anaesthesia-associated hypothermia on acid-base status and blood gases were studied in rats without assisted ventilation. 2. Manipulation of conscious rats produces a progressive increase in arterial lactate associated with slight hyperventilation. 3. Sodium pentobarbital anaesthesia produces mild respiratory acidosis accompanied by increase in lactate arterial values. Urethane anaesthesia leads to partially compensated metabolic acidosis. 4. Hypothermia reduces metabolic acidosis and hypercapnia induced by sodium pentobarbital anaesthesia. No difference between hypothermic and normothermic values was observed in urethane anaesthesia.

摘要

在未进行辅助通气的大鼠中，研究了两种麻醉剂戊巴比妥钠和乌拉坦的作用，以及麻醉相关低温对酸碱状态和血气的影响。2. 对清醒大鼠进行操作会导致动脉乳酸逐渐增加，并伴有轻微的通气过度。3. 戊巴比妥钠麻醉会导致轻度呼吸性酸中毒，并伴有动脉乳酸值升高。乌拉坦麻醉会导致部分代偿性代谢性酸中毒。4. 低温可减轻戊巴比妥钠麻醉引起的代谢性酸中毒和高碳酸血症。在乌拉坦麻醉中，未观察到低温组和正常体温组之间存在差异。