Field K J, White W J, Lang C M
Pennsylvania State University, Milton S. Hershey Medical Center, Department of Comparative Medicine, Hershey 17033.
Lab Anim. 1993 Jul;27(3):258-69. doi: 10.1258/002367793780745471.
Chloral hydrate, pentobarbitone and urethane were evaluated and compared for onset, duration and depth of anaesthesia, cardiovascular and respiratory effects, nociception and mortality in adult male rats. Chloral hydrate (300 and 400 mg/kg) severely depressed the cardiovascular and respiratory systems. Duration of anaesthesia was linearly related to dose, and anaesthetic depth and analgesia were excellent. Pentobarbital (40 mg/kg) produced a short period of light surgical anaesthesia. Moderate to severe respiratory and cardiovascular depression occurred. Duration of anaesthesia was not related to dose. Urethane (1.2 and 1.5 g/kg) caused moderate cardiovascular depression. In addition, mortality was high at the 1.5 g/kg dose. Duration of anaesthesia was greater than 24 h for most animals. Anaesthesia depth and analgesia were excellent.
对水合氯醛、戊巴比妥和乌拉坦进行了评估，并比较了它们在成年雄性大鼠中的麻醉起效时间、持续时间和深度、心血管和呼吸效应、痛觉感受及死亡率。水合氯醛（300和400毫克/千克）严重抑制心血管和呼吸系统。麻醉持续时间与剂量呈线性关系，麻醉深度和镇痛效果良好。戊巴比妥（40毫克/千克）产生短时间的浅度外科麻醉。出现中度至重度的呼吸和心血管抑制。麻醉持续时间与剂量无关。乌拉坦（1.2和1.5克/千克）引起中度心血管抑制。此外，1.5克/千克剂量时死亡率很高。大多数动物的麻醉持续时间超过24小时。麻醉深度和镇痛效果良好。
