le RICHE W
Can Med Assoc J. 1963 Apr 20;88(16):837-41.
Six hypnotic drugs and a placebo were coded and administered at random, one dose at 8 p.m., to 20 patients in a Toronto hospital. A special evaluation scale was used, studying average duration of sleep, time of onset of sleep, quality of sleep and side effects. Secobarbital sodium and methyprylon were statistically significantly more effective than the placebo. The other drugs, glutethimide and three quinozolinone derivatives, were not statistically different from the placebo in their effects. The placebo effect itself was studied. A particular feature of this report is the detailed statistical treatment of the data collected.
六种催眠药物和一种安慰剂被编码并随机给药，晚上8点服用一剂，给多伦多一家医院的20名患者。使用了一种特殊的评估量表，研究睡眠的平均持续时间、入睡时间、睡眠质量和副作用。司可巴比妥钠和甲乙哌酮在统计学上比安慰剂更有效。其他药物，格鲁米特和三种喹唑啉酮衍生物，在效果上与安慰剂没有统计学差异。对安慰剂效应本身进行了研究。本报告的一个特别之处是对收集到的数据进行了详细的统计处理。
