Papageorgiou I, Tsionou C, Minaretzis D, Michalas S, Aravantinos D
First Department of Obstetrics and Gynecology, University of Athens, Alexandra Maternity Hospital, Greece.
Gynecol Obstet Invest. 1992;34(2):92-6. doi: 10.1159/000292734.
Labor characteristics after intracervical application of 0.5 mg prostaglandin (PG) E2 gel (n = 83) versus intravenous administration of oxytocin (n = 82) for labor induction were investigated in uncomplicated prolonged pregnancies with unripe cervix. The induction to delivery time as well as the total oxytocin dose were significantly reduced in the PGE2 group (p < 0.001). Cesarean sections, instrumental deliveries and fetal distress had the same frequency, but the failures of trial were significantly higher in the oxytocin group than in the PGE2 group (20.7 vs. 6%, p < 0.01). Twenty-four percent of women needed a second PGE2 dose, and almost half of the women in the PGE2 group experienced 'spontaneous' labor. More neonates in the oxytocin group had 5-min Apgar scores < 7 (p < 0.05). Intracervical PGE2 gel application is superior to intravenous oxytocin in terms of shortening the induction-delivery interval and increasing the frequency of successful vaginal delivery. In addition, it is safe for mother and fetus.
在宫颈未成熟的单纯过期妊娠中，研究了83例宫颈内应用0.5毫克前列腺素（PG）E2凝胶与82例静脉滴注缩宫素引产的产程特征。PGE2组的引产至分娩时间以及缩宫素总剂量显著缩短（p < 0.001）。剖宫产、器械助产和胎儿窘迫的发生率相同，但缩宫素组的引产失败率显著高于PGE2组（20.7%对6%，p < 0.01）。24%的女性需要第二剂PGE2，PGE2组近一半的女性经历了“自然”分娩。缩宫素组更多新生儿的5分钟阿氏评分<7（p < 0.05）。宫颈内应用PGE2凝胶在缩短引产至分娩间隔和提高阴道分娩成功率方面优于静脉滴注缩宫素。此外，对母婴安全。
