山梨酸盐对叙利亚仓鼠胚胎成纤维细胞的遗传毒性和细胞转化研究。

Genotoxicity and cell transformation studies with sorbates in Syrian hamster embryo fibroblasts.

作者信息

Schiffmann D, Schlatter J

机构信息

Institute of Toxicology, University of Würzburg, Germany.

出版信息

Food Chem Toxicol. 1992 Aug;30(8):669-72. doi: 10.1016/0278-6915(92)90161-d.

DOI:10.1016/0278-6915(92)90161-d

PMID:1398347

Abstract

Sorbic acid, sodium sorbate and potassium sorbate were tested for their genotoxic potential in the Syrian hamster embryo (SHE) fibroblast micronucleus assay and the SHE cell transformation test in vitro. Sorbic acid and potassium sorbate showed no activity in either test system. When freshly prepared sodium sorbate solutions were used, no genotoxic or cell-transforming activity was detected. However, sodium sorbate as stored solution, which previously had been heated and sonicated to facilitate solubilization, yielded a positive response in both test systems. It is concluded that oxidation products of sodium sorbate that possess genotoxic and cell-transforming properties are formed under conditions of heating, sonication and storage.

摘要

在叙利亚仓鼠胚胎（SHE）成纤维细胞微核试验和体外SHE细胞转化试验中，对山梨酸、山梨酸钠和山梨酸钾的遗传毒性潜力进行了测试。山梨酸和山梨酸钾在这两种测试系统中均未表现出活性。当使用新制备的山梨酸钠溶液时，未检测到遗传毒性或细胞转化活性。然而，之前经过加热和超声处理以促进溶解的储存溶液形式的山梨酸钠，在这两种测试系统中均产生了阳性反应。得出的结论是，山梨酸钠的氧化产物在加热、超声处理和储存条件下形成，具有遗传毒性和细胞转化特性。