Karrer D, Baroncelli S, Ciaralli L, Turillazzi P G
Department of Comparative Toxicology and Ecotoxicology, Istituto Superiore di Sanità, Roma, Italy.
Food Chem Toxicol. 1992 Aug;30(8):715-8. doi: 10.1016/0278-6915(92)90168-k.
A preliminary study was conducted on adult male crab-eating monkeys (Macaca fascicularis) orally exposed to bis(tri-n-butyltin)oxide (TBTO) at doses of 0 and 160 micrograms/kg/day, 6 days/wk, for 22 wk. No treatment-related signs of toxicity or changes in body weight gain were detected during the course of the study. The haematological analyses performed every 2 wk indicated a decrease in total leucocyte count in the treated animals with significant values in wk 8, 10 and 22 of treatment. No differences from controls were noted in clinical chemistry and total tin concentration in blood. These preliminary data on the toxicity of TBTO in the primate model are intended to be an initial contribution towards a better evaluation of the potential toxicological hazard of TBTO to humans.
对成年雄性食蟹猴（猕猴）进行了一项初步研究，这些猴子每周6天口服双（三正丁基锡）氧化物（TBTO），剂量分别为0和160微克/千克/天，持续22周。在研究过程中未检测到与治疗相关的毒性迹象或体重增加变化。每2周进行的血液学分析表明，治疗组动物的白细胞总数减少，在治疗的第8、10和22周有显著数值。临床化学和血液中总锡浓度与对照组无差异。这些关于TBTO在灵长类动物模型中毒性的初步数据旨在为更好地评估TBTO对人类的潜在毒理学危害做出初步贡献。
