STEINER W G, PSCHEIDT G R, HIMWICH H E
Science. 1963 Jul 5;141(3575):53-5. doi: 10.1126/science.141.3575.53.
In studies with reserpine and with etryptamine, quite opposite electroencephalographic effects were obtained when either of these two drugs was administered to rabbits prior to surgical preparation for EEG recording as opposed to the drug being given after the rabbits had been fully prepared for EEG recording. With the one method, EEG rhythms indicative of sleep were obtained, while with the other method, EEG rhythms indicative of central nervous system stimulation were obtained, although with both methods, the amount of drug, duration of drug in animal, and type of acute preparation were identical for both sets of findings. The presurgical injection procedure produced EEG results more in accordance with behavioral and biochemical findings, even though the conventional procedure is to administer the experimental drug after the animal has been prepared for EEG recording.
在使用利血平和色胺的研究中，当在对兔子进行脑电图记录的手术准备之前给予这两种药物中的任何一种时，与在兔子完全准备好进行脑电图记录后给予药物相比，获得了完全相反的脑电图效应。采用一种方法时，获得了指示睡眠的脑电图节律，而采用另一种方法时，获得了指示中枢神经系统刺激的脑电图节律，尽管对于两组结果而言，药物的用量、药物在动物体内的持续时间以及急性准备的类型都是相同的。术前注射程序产生的脑电图结果更符合行为和生化研究结果，尽管传统程序是在动物准备好进行脑电图记录后给予实验药物。
