TAKESHIGE C, VOLLE R L
Br J Pharmacol Chemother. 1963 Feb;20(1):214-20. doi: 10.1111/j.1476-5381.1963.tb01311.x.
Neostigmine injected intra-arterially to the superior cervical ganglion of the cat evoked an asynchronous postganglionic nervous discharge in both normal and denervated superior cervical ganglia. This asynchronous firing was enhanced by tubocurarine but blocked by small doses of atropine. In addition, the responses evoked by acetylcholine in ganglia treated with neostigmine were characterized by two components. The first was blocked by tubocurarine and the second by atropine. Asynchronous firing evoked by repetitive preganglionic nerve stimulation of ganglia treated with neostigmine was blocked by atropine but not tubocurarine. It is suggested that neostigmine (1) has actions on ganglia other than those attributable to inactivation of cholinesterase, (2) may possess both pre- and post-synaptic sites of action, and (3) may unmask a cholinoceptive site which can be blocked by atropine.
动脉内注射新斯的明至猫的颈上神经节，在正常和去神经的颈上神经节中均可诱发节后神经的异步放电。筒箭毒碱可增强这种异步放电，但小剂量阿托品可阻断它。此外，在用新斯的明处理的神经节中，乙酰胆碱诱发的反应具有两个成分。第一个成分被筒箭毒碱阻断，第二个成分被阿托品阻断。用新斯的明处理的神经节经节前神经重复刺激诱发的异步放电被阿托品阻断，但不被筒箭毒碱阻断。提示新斯的明(1)对神经节有除胆碱酯酶失活作用之外的其他作用，(2)可能具有突触前和突触后作用部位，(3)可能暴露了一个可被阿托品阻断的胆碱能感受部位。
