MASON D F
Br J Pharmacol Chemother. 1962 Feb;18(1):76-86. doi: 10.1111/j.1476-5381.1962.tb01152.x.
The actions of neostigmine on transmission in the superior cervical ganglion have been investigated by means of the nictitating membrane preparation in the anaesthetized cat. Intravenous injections of neostigmine produced a rapid and often complete reversal of hexamethonium block, whereas eserine had no effect. This reversal by neostigmine was obtained regularly even after large doses of eserine or dyflos, but was sometimes brief. In ganglia perfused with heparinized plasma containing neostigmine (10(-8) to 10(-4)), there was no potentiation of the responses to maximal stimulation of the preganglionic nerve. Intra-arterial injections of neostigmine to both normal and preganglionically denervated ganglia produced first a potentiation of the responses to nicotine, then, with larger doses, a contraction of the nictitating membrane and, concurrently, a depression of the responses to nicotine. These results are consistent with the view that neostigmine exerts a direct stimulant action on the ganglion, which is distinct from its anticholinesterase action.
已通过麻醉猫的瞬膜制备法研究了新斯的明对上颈神经节传递的作用。静脉注射新斯的明可迅速且常常完全逆转六甲铵阻滞，而毒扁豆碱则无此作用。即使在给予大剂量毒扁豆碱或双氟磷后，新斯的明的这种逆转作用仍能正常获得，但有时持续时间较短。在用含新斯的明（10⁻⁸至10⁻⁴）的肝素化血浆灌注的神经节中，对节前神经最大刺激的反应并无增强。向正常和节前神经去神经的神经节内动脉注射新斯的明，起初会增强对烟碱的反应，然后，剂量增大时，会引起瞬膜收缩，同时会抑制对烟碱的反应。这些结果与新斯的明对神经节发挥直接兴奋作用的观点一致，这一作用与其抗胆碱酯酶作用不同。
