叶酸对苯丙酮尿症患者苯丙氨酸耐量试验的影响。
Effects of folic acid on the phenylalanine tolerance test in phenylketonuria.
作者信息
TISCHLER B, McGEER E G
出版信息
Can Med Assoc J. 1962 Dec 22;87(25):1331-2.
Abstract
Phenylalanine tolerance tests were performed on four untreated children with phenylketonuria, aged 8 to 12 years, before and after 14 days of folic acid administration (70 mg./day). No significant changes were noted in the phenylalanine tolerance tests or in the general condition of the patients. This study was carried out because of recent findings that a folic acid derivative is a co-factor in the conversion of phenylalanine to tyrosine.
摘要
对4名年龄在8至12岁、未经治疗的苯丙酮尿症患儿进行了苯丙氨酸耐量试验，分别在给予叶酸（70毫克/天）14天之前和之后进行。苯丙氨酸耐量试验及患儿的一般状况均未发现显著变化。开展这项研究是因为最近有研究发现一种叶酸衍生物是苯丙氨酸转化为酪氨酸过程中的一种辅助因子。
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本文引用的文献
1
Further studies on the phenylalanine-hydroxylation cofactor.苯丙氨酸羟化辅因子的进一步研究。
J Biol Chem. 1959 Oct;234:2683-8.
2
Phenylalanine hydroxylation cofactor in phenylketonuria.苯丙酮尿症中的苯丙氨酸羟化辅因子。
Science. 1958 Dec 12;128(3337):1506-8. doi: 10.1126/science.128.3337.1506.
3
On the nature of enzymatic defect in phenylpyruvic oligophrenia.
Proc Soc Exp Biol Med. 1957 Apr;94(4):634-5. doi: 10.3181/00379727-94-23034.
4
Detection by phenylalanine tolerance tests of heterozygous carriers of phenylketonuria.通过苯丙氨酸耐量试验检测苯丙酮尿症杂合子携带者。
Nature. 1956 Dec 1;178(4544):1239-40. doi: 10.1038/1781239a0.
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