Mathew P, John L, Jose J, Krishnaswami S
Christian Medical College Hospital, Vellore.
Indian Heart J. 1992 Jan-Feb;44(1):29-32.
Left ventricular diastolic function was assessed in 21 young diabetic subjects (less than 35 years) by Doppler transmitral flow velocity examination and compared with an equal number of matched controls. Diabetic subjects had higher heart rates (89 +/- 2 vs 79 +/- 4 beats/minute, p less than 0.015), peak late diastolic (A) velocity and a velocity time integral (56.6 +/- 13.4 vs 45.3 +/- 11.4 cm/sec. p less than 0.005 and 7.3 +/- 5.2 vs 6.5 +/- 2.5 cm p less than 0.03 respectively) and total transmitral flow velocity integral (25.8 +/- 5 vs 22 +/- 3.2 cm, p less than 0.05). Peak E velocities, E velocity time integrals, E/A ratio, and peak filling rates were similar in two groups (p = not significant). These data suggests that young patients with diabetes mellitus have normal left ventricular diastolic function. The minor transmitral flow abnormalities are possibly due to autonomic dysfunction, e.g. increased sympathetic activity resulting in increased heart rate and cardiac output.
通过多普勒二尖瓣血流速度检查对21名年轻糖尿病患者（年龄小于35岁）的左心室舒张功能进行评估，并与同等数量的匹配对照进行比较。糖尿病患者的心率较高（89±2对79±4次/分钟，p<0.015），舒张晚期峰值（A）速度和速度时间积分（分别为56.6±13.4对45.3±11.4厘米/秒，p<0.005；7.3±5.2对6.5±2.5厘米，p<0.03）以及二尖瓣总血流速度积分（25.8±5对22±3.2厘米，p<0.05）。两组的E峰速度、E速度时间积分、E/A比值和峰值充盈率相似（p=无显著性差异）。这些数据表明，年轻糖尿病患者的左心室舒张功能正常。轻微的二尖瓣血流异常可能是由于自主神经功能障碍，例如交感神经活动增加导致心率和心输出量增加。
