γ干扰素对小鼠衣原体性生殖道感染消退的影响。
Effect of gamma interferon on resolution of murine chlamydial genital infection.
作者信息
Rank R G, Ramsey K H, Pack E A, Williams D M
机构信息
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock 72205.
出版信息
Infect Immun. 1992 Oct;60(10):4427-9. doi: 10.1128/iai.60.10.4427-4429.1992.
Abstract
Mice infected in the genital tract with the Chlamydia trachomatis agent of mouse pneumonitis were treated with monoclonal rat anti-gamma interferon (anti-IFN-gamma) antibody to determine whether IFN-gamma participated in the resolution of the infection. In two experiments, anti-IFN-gamma antibody treatment resulted in significantly prolonged infections. In support of these data, passive administration of recombinant IFN-gamma to chronically infected nu/nu mice was able to bring about resolution of the infection in some animals.
摘要
用小鼠肺炎衣原体感染生殖道的小鼠，并用大鼠抗γ干扰素（抗IFN-γ）单克隆抗体进行治疗，以确定IFN-γ是否参与感染的消退过程。在两项实验中，抗IFN-γ抗体治疗导致感染显著延长。为支持这些数据，对慢性感染的裸鼠被动给予重组IFN-γ能够使一些动物的感染得到消退。
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