γ干扰素在小鼠体内对沙眼衣原体所致肺炎的控制作用。
Role in vivo for gamma interferon in control of pneumonia caused by Chlamydia trachomatis in mice.
作者信息
Williams D M, Byrne G I, Grubbs B, Marshal T J, Schachter J
机构信息
Audie L. Murphy Memorial Veterans' Hospital, University of Texas Health Science Center, San Antonio 78284.
出版信息
Infect Immun. 1988 Nov;56(11):3004-6. doi: 10.1128/iai.56.11.3004-3006.1988.
Abstract
In a model of pneumonia caused by murine Chlamydia trachomatis, depletion experiments with monoclonal antibody to gamma interferon (IFN-gamma) made mice more susceptible. Repletion experiments giving exogenous recombinant murine IFN-gamma were not consistently protective. IFN-gamma may be necessary but not sufficient in host defense against the organism.
摘要
在小鼠沙眼衣原体引起的肺炎模型中，用抗γ干扰素（IFN-γ）单克隆抗体进行的耗竭实验使小鼠更易感染。给予外源性重组小鼠IFN-γ的补充实验并未始终具有保护作用。IFN-γ在宿主抵御该病原体的防御中可能是必要的，但并不充分。
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本文引用的文献
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