γ干扰素在小鼠体内对沙眼衣原体所致肺炎的控制作用。
Role in vivo for gamma interferon in control of pneumonia caused by Chlamydia trachomatis in mice.
作者信息
Williams D M, Byrne G I, Grubbs B, Marshal T J, Schachter J
机构信息
Audie L. Murphy Memorial Veterans' Hospital, University of Texas Health Science Center, San Antonio 78284.
出版信息
Infect Immun. 1988 Nov;56(11):3004-6. doi: 10.1128/iai.56.11.3004-3006.1988.
Abstract
In a model of pneumonia caused by murine Chlamydia trachomatis, depletion experiments with monoclonal antibody to gamma interferon (IFN-gamma) made mice more susceptible. Repletion experiments giving exogenous recombinant murine IFN-gamma were not consistently protective. IFN-gamma may be necessary but not sufficient in host defense against the organism.
摘要
在小鼠沙眼衣原体引起的肺炎模型中，用抗γ干扰素（IFN-γ）单克隆抗体进行的耗竭实验使小鼠更易感染。给予外源性重组小鼠IFN-γ的补充实验并未始终具有保护作用。IFN-γ在宿主抵御该病原体的防御中可能是必要的，但并不充分。
相似文献
1
Role in vivo for gamma interferon in control of pneumonia caused by Chlamydia trachomatis in mice.γ干扰素在小鼠体内对沙眼衣原体所致肺炎的控制作用。
Infect Immun. 1988 Nov;56(11):3004-6. doi: 10.1128/iai.56.11.3004-3006.1988.
2
Role of endogenous gamma interferon in host defense against Chlamydia trachomatis infections.内源性γ干扰素在宿主抵御沙眼衣原体感染中的作用。
Infect Immun. 1989 Jan;57(1):152-7. doi: 10.1128/iai.57.1.152-157.1989.
3
Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis.鼠沙眼衣原体继发感染中的体液免疫和细胞免疫。
Infect Immun. 1997 Jul;65(7):2876-82. doi: 10.1128/iai.65.7.2876-2882.1997.
4
Less inhibition of interferon-gamma to organism growth in host cells may contribute to the high susceptibility of C3H mice to Chlamydia trachomatis lung infection.宿主细胞中干扰素-γ对机体生长的抑制作用减弱可能导致C3H小鼠对沙眼衣原体肺部感染高度易感。
Immunology. 2004 Apr;111(4):453-61. doi: 10.1111/j.0019-2805.2004.01835.x.
5
Gamma interferon levels during Chlamydia trachomatis pneumonia in mice.小鼠沙眼衣原体肺炎期间的γ干扰素水平。
Infect Immun. 1993 Aug;61(8):3556-8. doi: 10.1128/iai.61.8.3556-3558.1993.
6
7
Inhibition of chlamydia trachomatis growth by human interferon-alpha: mechanisms and synergistic effect with interferon-gamma and tumor necrosis factor-alpha.
Biomed Res. 2005 Aug;26(4):179-85. doi: 10.2220/biomedres.26.179.
8
Effect of gamma interferon on resolution of murine chlamydial genital infection.γ干扰素对小鼠衣原体性生殖道感染消退的影响。
Infect Immun. 1992 Oct;60(10):4427-9. doi: 10.1128/iai.60.10.4427-4429.1992.
9
Gamma interferon-mediated cytotoxicity related to murine Chlamydia trachomatis infection.γ干扰素介导的与鼠沙眼衣原体感染相关的细胞毒性
Infect Immun. 1988 Aug;56(8):2023-7. doi: 10.1128/iai.56.8.2023-2027.1988.
10
Recombinant murine gamma interferon inhibits Chlamydia trachomatis serovar L1 in vivo.重组鼠γ干扰素在体内抑制沙眼衣原体L1血清型。
Infect Immun. 1988 Jan;56(1):283-6. doi: 10.1128/iai.56.1.283-286.1988.
引用本文的文献
1
Murine modeling of menstruation identifies immune correlates of protection during challenge.月经的小鼠模型确定了挑战期间保护作用的免疫相关因素。
bioRxiv. 2024 May 23:2024.05.21.595090. doi: 10.1101/2024.05.21.595090.
2
A review of immune modulators and immunotherapy in infectious diseases.免疫调节剂和免疫疗法在传染病中的研究进展。
Mol Cell Biochem. 2024 Aug;479(8):1937-1955. doi: 10.1007/s11010-023-04825-w. Epub 2023 Sep 8.
3
IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections.IFNγ 和抗体协同作用增强对衣原体传播和女性生殖道再感染的保护免疫。
Infect Immun. 2022 Dec 15;90(12):e0032822. doi: 10.1128/iai.00328-22. Epub 2022 Nov 14.
4
Insights Into Host Cell Cytokines in Infection.宿主细胞细胞因子在 感染中的作用机制
Front Immunol. 2021 May 21;12:639834. doi: 10.3389/fimmu.2021.639834. eCollection 2021.
5
6
Innate immunity is sufficient for the clearance of Chlamydia trachomatis from the female mouse genital tract.先天性免疫足以清除雌性小鼠生殖道中的沙眼衣原体。
Pathog Dis. 2014 Oct;72(1):70-3. doi: 10.1111/2049-632X.12164. Epub 2014 Apr 10.
7
Anti-chlamydial Th17 responses are controlled by the inducible costimulator partially through phosphoinositide 3-kinase signaling.抗衣原体 Th17 反应受诱导共刺激分子部分控制，部分通过磷酸肌醇 3-激酶信号通路。
PLoS One. 2012;7(12):e52657. doi: 10.1371/journal.pone.0052657. Epub 2012 Dec 20.
8
T lymphocyte immunity in host defence against Chlamydia trachomatis and its implication for vaccine development.T淋巴细胞免疫在宿主抵御沙眼衣原体中的作用及其对疫苗研发的意义。
Can J Infect Dis. 1998 Mar;9(2):99-108. doi: 10.1155/1998/395297.
9
The contribution of interleukin-12/interferon-gamma axis in protection against neonatal pulmonary Chlamydia muridarum challenge.白细胞介素-12/干扰素-γ 轴在抗新生鼠肺炎衣原体感染中的作用。
J Interferon Cytokine Res. 2010 Jun;30(6):407-15. doi: 10.1089/jir.2009.0083.
10
Acquired immunity to Chlamydia pneumoniae is dependent on gamma interferon in two mouse strains that initially differ in this respect after primary challenge.在初次感染后最初在这方面存在差异的两种小鼠品系中，对肺炎衣原体的获得性免疫依赖于γ干扰素。
Infect Immun. 2000 Feb;68(2):960-4. doi: 10.1128/IAI.68.2.960-964.2000.
本文引用的文献
1
Effect of Interferon and Interferon Inducers on Infections with a Nonviral Intracellular Microorganism, Chlamydia trachomatis.干扰素和干扰素诱导剂对非病毒细胞内微生物沙眼衣原体感染的影响。
Infect Immun. 1971 Jun;3(6):825-32. doi: 10.1128/iai.3.6.825-832.1971.
2
Pneumonia due to Chlamydia trachomatis in the immunocompromised (nude) mouse.免疫功能低下（裸）小鼠的沙眼衣原体肺炎
J Infect Dis. 1981 Feb;143(2):238-41. doi: 10.1093/infdis/143.2.238.
3
The role of antibody in host defense against the agent of mouse pneumonitis.抗体在宿主抵御小鼠肺炎病原体中的作用。
J Infect Dis. 1982 Feb;145(2):200-5. doi: 10.1093/infdis/145.2.200.
4
Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activities.抗小鼠γ干扰素单克隆抗体可抑制淋巴因子诱导的抗病毒及巨噬细胞杀肿瘤活性。
J Exp Med. 1984 May 1;159(5):1560-5. doi: 10.1084/jem.159.5.1560.
5
Lymphokine-mediated inhibition of Chlamydia replication in mouse fibroblasts is neutralized by anti-gamma interferon immunoglobulin.抗γ干扰素免疫球蛋白可中和淋巴细胞因子介导的对小鼠成纤维细胞中衣原体复制的抑制作用。
Infect Immun. 1983 Dec;42(3):1152-8. doi: 10.1128/iai.42.3.1152-1158.1983.
6
7
Cellular immunity to the mouse pneumonitis agent.
J Infect Dis. 1984 Apr;149(4):630-9. doi: 10.1093/infdis/149.4.630.
8
9
Role of natural killer cells in infection with the mouse pneumonitis agent (murine Chlamydia trachomatis).自然杀伤细胞在小鼠肺炎病原体（鼠沙眼衣原体）感染中的作用。
Infect Immun. 1987 Jan;55(1):223-6. doi: 10.1128/iai.55.1.223-226.1987.
10
The effect of gamma-interferon during Mycobacterium bovis (BCG) infection in athymic and euthymic mice.
Microb Pathog. 1986 Apr;1(2):221-4. doi: 10.1016/0882-4010(86)90024-0.
Zotero 插件