de Angelis E, Lombardi M L, Grassi M, Ruocco V
Servizio di Oncologia Sperimentale D Farmaco-Chemioterapia, I Facoltà di Medicina, Università di Napoli Federico II, Italy.
Int J Dermatol. 1992 Oct;31(10):722-4. doi: 10.1111/j.1365-4362.1992.tb01383.x.
Drugs containing sulfhydryl groups (thiol drugs) (e.g., penicillamine, captopril, thiopronine) can induce pemphigus in vivo and provoke acantholysis in vitro. Enalapril, like captopril, is an angiotensin-converting enzyme (ACE) inhibitor largely used as an antihypertensive drug; it has recently been reported to induce pemphigus, though it is not a thiol drug. In this study we investigated the possible in vitro acantholytic effect of enalapril on normal human skin from donors. The drug induced severe acantholytic changes of keratinocytes and complete suprabasal splitting at one tenth the concentration required by thiol drugs in similar experiments, even after a shorter period of culture. All skin samples from different donors was highly susceptible to the acantholytic effect of enalapril. In our experience, enalapril is the most powerful acantholytic drug in vitro.
含巯基的药物（硫醇类药物）（如青霉胺、卡托普利、硫普罗宁）可在体内诱发天疱疮，并在体外引起棘层松解。依那普利与卡托普利一样，是一种主要用作抗高血压药物的血管紧张素转换酶（ACE）抑制剂；最近有报道称它可诱发天疱疮，尽管它不是硫醇类药物。在本研究中，我们调查了依那普利对供体正常人类皮肤可能的体外棘层松解作用。在类似实验中，该药物在培养较短时间后，就能以硫醇类药物所需浓度的十分之一诱发角质形成细胞严重的棘层松解变化和完全的基底层上分离。来自不同供体的所有皮肤样本对依那普利的棘层松解作用都高度敏感。根据我们的经验，依那普利是体外最强效的棘层松解药物。
