Blau A, Herzog D, Shechter P, Eliahou H E
Department of Nephrology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Isr J Med Sci. 1992 Oct;28(10):688-93.
The antihypertensive effect of nisoldipine on ambulatory blood pressure was investigated using continuous noninvasive monitoring in 12 patients with moderate essential hypertension. Treatment with nisoldipine 5 mg twice a day for 2 weeks resulted in a decrease in the average of each patient's mean arterial pressure for the whole day from 110.3 +/- 6.8 to 103.2 +/- 8.8 mm Hg (P = 0.0007). This decrease in mean arterial pressure was due to a decrease in both systolic and diastolic pressures. The reduction in blood pressure was most marked at the time of the originally high blood pressure readings. Comparisons of consecutive means of 2-hourly mean arterial pressure readings showed a statistically significant effect from 6:00 AM to midnight. Blood pressures between midnight and 6:00 AM were similarly low, before and during nisoldipine therapy. There was no change in heart rate. Untoward symptoms were reported with similar frequency, and of similar severity, both before and during therapy. Nisoldipine 5 mg twice a day is an effective antihypertensive agent, reducing moderately elevated blood pressure in ambulatory, working patients with essential hypertension. At the dosage used, it had no demonstrable effect on heart rate and minimal, if any, side effects.
采用连续无创监测方法，对12例中度原发性高血压患者研究了尼索地平对动态血压的降压作用。每天两次服用5毫克尼索地平，持续治疗2周，使得每位患者全天平均动脉压从110.3±6.8毫米汞柱降至103.2±8.8毫米汞柱（P = 0.0007）。平均动脉压的下降是由于收缩压和舒张压均降低所致。血压下降在原本血压较高时最为明显。对每两小时平均动脉压读数的连续均值进行比较显示，从上午6:00至午夜有统计学显著效果。在尼索地平治疗前和治疗期间，午夜至上午6:00的血压同样较低。心率无变化。治疗前和治疗期间报告的不良症状频率和严重程度相似。每天两次服用5毫克尼索地平是一种有效的抗高血压药物，可降低动态血压中度升高的原发性高血压在职患者的血压。在所使用的剂量下，它对心率没有明显影响，副作用极少（如果有的话）。
