Blau A, Herzog D, Herz I, Battler A, Schechter P, Eliahou H E
Department of Nephrology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Isr J Med Sci. 1994 Feb;30(2):139-45.
The acute hemodynamic effects of nisoldipine (Bay K552) in patients with essential hypertension were studied using nuclear ventriculography. In a cohort of 16 essential hypertension patients, an oral dose of 15 mg nisoldipine significantly lowered blood pressure within 20 min. The effect lasted at least 3 h. Blood pressure that was 160.5 +/- 20.3/108.0 +/- 10.1 mm Hg initially was reduced to 137.0 +/- 14.9/93.8 +/- 9.4 mm Hg at 3 h (P < 0.001). Cardiac output rose, total peripheral resistance fell and ejection fraction rose significantly. End systolic and end diastolic volumes did not change significantly with this dose of nisoldipine. The acute hemodynamic effects of 15 mg nisoldipine administered orally, measured by repeat nuclear ventriculography, were maintained during therapy for the 8 weeks of observation. Thus, nisoldipine is a powerful antihypertensive agent, significantly decreasing BP as well as total peripheral resistance and increasing cardiac index. This effect was prominent after 3 h and wore off about 12 h after each dose. Five of the patients had an initially high heart rate. To these patients propranolol was added in small doses (20-40 mg/day, mean 25 +/- 26 mg/day). This addition did not change the results when the patients were analyzed separately.
采用核心室造影术研究了尼索地平（Bay K552）对原发性高血压患者的急性血流动力学影响。在16例原发性高血压患者队列中，口服15mg尼索地平后20分钟内血压显著降低。该作用至少持续3小时。初始血压为160.5±20.3/108.0±10.1mmHg，3小时时降至137.0±14.9/93.8±9.4mmHg（P<0.001）。心输出量增加，总外周阻力降低，射血分数显著升高。使用该剂量尼索地平后，收缩末期和舒张末期容积无显著变化。通过重复核心室造影测量，口服15mg尼索地平的急性血流动力学效应在8周观察期的治疗过程中持续存在。因此，尼索地平是一种强效抗高血压药物，可显著降低血压以及总外周阻力并增加心脏指数。该效应在3小时后显著，且每次给药后约12小时逐渐消失。5例患者初始心率较高。对这些患者小剂量添加普萘洛尔（20 - 40mg/天，平均25±26mg/天）。单独分析患者时，这种添加并未改变结果。
