Rassin T, Liron M, Rubinstein A, Arad J, Weintraub M
Department of Internal Medicine E, Rokach (Hadassah) Hospital, Tel Aviv Medical Center, Israel.
Isr J Med Sci. 1992 Oct;28(10):706-10.
To study post-prandial lipoprotein metabolism in normolipidemic and hypertriglyceridemic subjects, a vitamin A fat loading test was used. This method specifically labels dietary fat particles with retinyl palmitate (RP). Following RP concentrations, metabolic behavior of chylomicrons and chylomicron remnants were studied. In normal subjects, post-prandial lipoproteins were present for more than 10 h. Total RP increased rapidly between 1 and 4 h, peaked at 6 h and declined rapidly between 6 and 10 h. The chylomicron and chylomicron remnant fractions behaved differently, showing precursor product relationship. The hypertriglyceridemic patients demonstrated a very severe defect in chylomicron clearance. This fraction was 2.8-fold higher than in normal subjects, which was 7,260 vs. 2,600 micrograms/l, respectively. The large magnitude and long duration of post-prandial lipemia in normal and hypertriglyceridemic patients support the hypothesis that these atherogenic particles may play a role in the development of coronary heart disease.
为研究血脂正常和高甘油三酯血症患者的餐后脂蛋白代谢，采用了维生素A脂肪负荷试验。该方法用棕榈酸视黄酯（RP）特异性标记膳食脂肪颗粒。通过追踪RP浓度，研究乳糜微粒和乳糜微粒残粒的代谢行为。在正常受试者中，餐后脂蛋白存在超过10小时。总RP在1至4小时之间迅速增加，在6小时达到峰值，并在6至10小时之间迅速下降。乳糜微粒和乳糜微粒残粒部分表现不同，呈现前体产物关系。高甘油三酯血症患者在乳糜微粒清除方面表现出非常严重的缺陷。该部分比正常受试者高2.8倍，分别为7260微克/升和2600微克/升。正常和高甘油三酯血症患者餐后血脂的大幅升高和长时间持续支持了这些致动脉粥样硬化颗粒可能在冠心病发展中起作用的假说。
