Fedorova K N, Spitkovskiĭ D M, Seregina V N
Biull Eksp Biol Med. 1977 Mar;83(3):353-5.
A method of fluorescent microscopy with the aid of acridine orange was applied in these studies; some features of the changes in the structure of interphasic chromatin characteristic of their sick children were revealed on the short-term cultures of lymphoyctes obtained from the mothers with children suffering from Down's syndrome. Sibling girls also displayed deviations similar to the changes revealed in their mothers. The data obtained permit to suppose the existence of a definite population of women, peculiarities of whose genotype promoted the appearance on the structural chromatin organization was revealed only in the mothers and sibling girls it is suggested that the mentioned genotype peculiarities were hereditary and connected with genes (or certain chromatin areas) limited by sex.
在这些研究中应用了借助吖啶橙的荧光显微镜检查方法；在从患有唐氏综合征孩子的母亲那里获得的淋巴细胞短期培养物中，揭示了其患病孩子间期染色质结构变化的一些特征。姐妹女孩也表现出与她们母亲所显示的变化相似的偏差。所获得的数据使人们能够推测存在一定数量的女性，其基因型的特殊性促进了染色质结构组织外观的出现，这种特殊性仅在母亲和姐妹女孩中被揭示，表明上述基因型特殊性是遗传性的，并且与受性别限制的基因（或某些染色质区域）有关。
