Fedorova K N
J Ment Defic Res. 1977 Jun;21(2):85-93. doi: 10.1111/j.1365-2788.1977.tb00028.x.
In an earlier publication we reported that, by using fluorescent microscopy with acridine orange (AO), we detected certain changes in the structure and function of interphase nuclear chromatin of peripheral blood lymphocytes of subjects with Down's disease (Fedorova, Inshakova and Spitkovsky, 1975). By employing the same method with additional thermal action on the cells studied it was shown that some of these changes were conditioned by the effect of the blood serum from a person with Down's syndrome (Fedorova and Spitkovsky, 1976). The purpose of the present work was to investigate the structure of the interphase chromatin of both disomic and trisomic human cells residing in the same serum, that is, in mosaic subjects. Small lymphocytes in the peripheral blood of mosaic mongols were selected for study, complete trisomic mongols and healthy subjects being used as controls.
在早期的一篇出版物中我们报道，通过使用吖啶橙（AO）荧光显微镜，我们检测到唐氏综合征患者外周血淋巴细胞间期核染色质的结构和功能发生了某些变化（费多罗娃、因沙科娃和斯皮特科夫斯基，1975年）。通过对所研究的细胞施加额外热作用的相同方法表明，其中一些变化是由唐氏综合征患者血清的作用所引起的（费多罗娃和斯皮特科夫斯基，1976年）。本研究的目的是研究处于同一血清中的二体和三体人类细胞，即嵌合体受试者中间期染色质的结构。选择嵌合型蒙古人外周血中的小淋巴细胞进行研究，以完全三体性蒙古人和健康受试者作为对照。
