Gluck S L
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
J Bioenerg Biomembr. 1992 Aug;24(4):351-9. doi: 10.1007/BF00762528.
Vacuolar H+ ATPases participate in renal hydrogen ion secretion in both the proximal and distal nephron. These plasma membrane forms of the vacuolar H+ ATPase are regulated physiologically to maintain the acid-base balance of the organism. Proton transporting renal cells have requirements for constitutive acidification of intracellular compartments for normal endocytic and secretory functions. Recent experiments have begun to reveal how the kidney regulates these proton pumps independently. Vacuolar H+ ATPases are a family of structurally similar enzyme which differ in the composition of specific subunits. Cytosolic regulatory enzymes are present in renal cells which may affect vacuolar H+ ATPases in certain membrane compartments selectively. The vacuolar H+ ATPase in the plasma membrane of intercalated cells resides in a specialized proton-transporting apparatus that translocates the enzyme between an intracellular membrane pool and the plasma membrane in response to physiologic stimuli.
液泡型H⁺-ATP酶参与近端和远端肾单位的肾脏氢离子分泌。液泡型H⁺-ATP酶的这些质膜形式在生理上受到调节，以维持机体的酸碱平衡。质子转运肾细胞对细胞内区室的组成性酸化有需求，以实现正常的内吞和分泌功能。最近的实验已开始揭示肾脏如何独立调节这些质子泵。液泡型H⁺-ATP酶是一类结构相似的酶家族，其特定亚基的组成有所不同。肾细胞中存在胞质调节酶，它们可能选择性地影响某些膜区室中的液泡型H⁺-ATP酶。闰细胞质膜中的液泡型H⁺-ATP酶存在于一种特殊的质子转运装置中，该装置可响应生理刺激使酶在细胞内膜池和质膜之间转运。
