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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Oparil S, Erinoff L, Cutilletta A

Clin Sci Mol Med Suppl. 1976 Dec;3:445s-459s.

Neither nerve-growth-factor antiserum (NGFAS) administered subcutaneously nor 6-hydroxydopamine administered intraventricularly to immature spontaneously hypertensive rats (SHR) inhibited the development of the hypertensive syndrome. In contrast, NGFSA did not affect blood pressure in normotensive Kyoto/Wistar rats. 2. Peripheral vascular resistance was increased and cardiac index decreased in both NGFAS and 6-hydroxydopamine-treated SHR despite preservation of normal blood pressure. 3 NGFAS treatment did not influence the development of left ventricular hypertrophy in SHR, despite the lowering of blood pressure. In contrast, 6-hydroxydopamine caused an attenuation in the development of left ventricular hypertrophy. 4. Indices of left ventricular contractility were depressed by NGFAS treatment but not by 6-hydroxydopamine. 5. Plasma renin activity was unaffected by NGFAS treatment and increased by 6-hydroxydopamine.

皮下注射神经生长因子抗血清（NGFAS）或向未成熟自发性高血压大鼠（SHR）脑室内注射6-羟基多巴胺，均不能抑制高血压综合征的发展。相比之下，NGFSA对正常血压的京都/威斯塔大鼠的血压没有影响。2. 尽管血压保持正常，但接受NGFAS和6-羟基多巴胺治疗的SHR的外周血管阻力均增加，心脏指数均降低。3. NGFAS治疗虽降低了血压，但对SHR左心室肥厚的发展没有影响。相比之下，6-羟基多巴胺使左心室肥厚的发展有所减轻。4. NGFAS治疗使左心室收缩力指标降低，但6-羟基多巴胺没有此作用。5. NGFAS治疗对血浆肾素活性没有影响，而6-羟基多巴胺可使其升高。

Oparil S, Erinoff L, Cutilletta A

Clin Sci Mol Med Suppl. 1976 Dec;3:445s-459s.

Neither nerve-growth-factor antiserum (NGFAS) administered subcutaneously nor 6-hydroxydopamine administered intraventricularly to immature spontaneously hypertensive rats (SHR) inhibited the development of the hypertensive syndrome. In contrast, NGFSA did not affect blood pressure in normotensive Kyoto/Wistar rats. 2. Peripheral vascular resistance was increased and cardiac index decreased in both NGFAS and 6-hydroxydopamine-treated SHR despite preservation of normal blood pressure. 3 NGFAS treatment did not influence the development of left ventricular hypertrophy in SHR, despite the lowering of blood pressure. In contrast, 6-hydroxydopamine caused an attenuation in the development of left ventricular hypertrophy. 4. Indices of left ventricular contractility were depressed by NGFAS treatment but not by 6-hydroxydopamine. 5. Plasma renin activity was unaffected by NGFAS treatment and increased by 6-hydroxydopamine.

皮下注射神经生长因子抗血清（NGFAS）或向未成熟自发性高血压大鼠（SHR）脑室内注射6-羟基多巴胺，均不能抑制高血压综合征的发展。相比之下，NGFSA对正常血压的京都/威斯塔大鼠的血压没有影响。2. 尽管血压保持正常，但接受NGFAS和6-羟基多巴胺治疗的SHR的外周血管阻力均增加，心脏指数均降低。3. NGFAS治疗虽降低了血压，但对SHR左心室肥厚的发展没有影响。相比之下，6-羟基多巴胺使左心室肥厚的发展有所减轻。4. NGFAS治疗使左心室收缩力指标降低，但6-羟基多巴胺没有此作用。5. NGFAS治疗对血浆肾素活性没有影响，而6-羟基多巴胺可使其升高。