Cutilletta A F, Erinoff L, Heller A, Low J, Oparil S
Circ Res. 1977 Apr;40(4):428-34. doi: 10.1161/01.res.40.4.428.
The effects of peripheral sympathectomy with nerve growth factor antiserum (NGFAS) on blood pressure, systemic hemodynamics, myocardial function, myocardial hypertrophy, and renin were studied in male spontaneously hypertensive (SH) rats of the Okamoto strain and normotensive control Kyoto-Wistar (WKY) rats. NGFAS prevented the developing of hypertension in the SH rats but did not alter blood pressure in the WKY rats. The NGFAS-treated SH rats developed the same hemodynamic abnormalities as the sham-treated rats, including increased peripheral vascular resistance and depressed cardiac output; Indices of left ventricular performance, including peak flow velocity, stroke power, stroke work, dP/dtmax, and flow acceleration (dF/dt), were diminished in the SH rats compared to the WKY rats. NGFAS treatment further depressed ventricular function in the SH rats, but had little effect on the WKY rats; Plasma renin activity in both the SH and WKY rats was unaffected by NGFAS treatment. Although NGFAS treatment effectively prevented the development of hypertension in the SH rats, it did not influence the development of left ventricular hypertrophy as reflected by increases in left ventricular mass, RNA, DNA, and hydroxyproline content. The data suggest that the development of myocardial hypertrophy and myocardial dysfunction in the SH rat is in part independent of hypertension and plasma renin activity.
在冈本品系的雄性自发性高血压（SH）大鼠和正常血压对照京都-威斯塔大鼠（WKY）中，研究了用神经生长因子抗血清（NGFAS）进行外周交感神经切除术对血压、全身血流动力学、心肌功能、心肌肥大和肾素的影响。NGFAS可预防SH大鼠高血压的发展，但不改变WKY大鼠的血压。经NGFAS处理的SH大鼠出现了与假手术处理大鼠相同的血流动力学异常，包括外周血管阻力增加和心输出量降低；与WKY大鼠相比，SH大鼠的左心室功能指标，包括峰值流速、搏出功率、搏功、dP/dtmax和血流加速度（dF/dt）均降低。NGFAS处理进一步降低了SH大鼠的心室功能，但对WKY大鼠影响很小；NGFAS处理对SH和WKY大鼠的血浆肾素活性均无影响。尽管NGFAS处理有效地预防了SH大鼠高血压的发展，但它并未影响左心室肥大的发展，这可通过左心室质量、RNA、DNA和羟脯氨酸含量的增加反映出来。数据表明，SH大鼠心肌肥大和心肌功能障碍的发展部分独立于高血压和血浆肾素活性。
