Moeller M R
Institut für Rechtsmedizin, Universität des Saarlandes, Homburg/Saar, Germany.
J Chromatogr. 1992 Sep 16;580(1-2):125-34. doi: 10.1016/0378-4347(92)80532-u.
This article reviews the analysis of 31 drugs and drug metabolites in human hair by thin-layer chromatography, high-performance liquid chromatography, gas chromatography, gas chromatography-mass spectrometry and mass spectrometry. The most important detection method after chromatographic separation of the components is the mass spectrometry because of its sensitivity and specificity. Washing steps to exclude external contamination, extraction, derivatization, stationary phases, detection modes and detection limits of the mass spectrometric and gas chromatographic-mass spectrometric procedures are presented in five tables. Additionally, a method for a gas chromatographic-mass spectrometric screening procedure is presented.
本文综述了采用薄层色谱法、高效液相色谱法、气相色谱法、气相色谱 - 质谱联用法和质谱法对人发中31种药物及药物代谢物进行分析的情况。由于质谱具有灵敏度和特异性，因此在对各组分进行色谱分离后，最重要的检测方法就是质谱法。五个表格中列出了用于排除外部污染的清洗步骤、提取、衍生化、固定相、质谱及气相色谱 - 质谱联用程序的检测模式和检测限。此外，还介绍了一种气相色谱 - 质谱联用筛查程序的方法。
