Gaffney P J
Haemostasis. 1977;6(1):2-25. doi: 10.1159/000214161.
This is a brief review of the major events which take place when plasmin reacts with fibrinogen (fibrinogenolysis) and fibrin (fibrinolysis). An effort is made to interrelate the locations of the major products of fibrinogenolysis (X, Y, D and E) in the originating fibrinogen molecule. The complexity of the lysates of fibrins, cross-linked by factor XIII to varying extents, is discussed. Clinical and structural implications of two fragments (D dimer and the D dimer-E complex) unique to cross-linked fibrin digests, are highlighted.
本文简要回顾了纤溶酶与纤维蛋白原（纤维蛋白原溶解）和纤维蛋白（纤维蛋白溶解）反应时发生的主要事件。我们努力将纤维蛋白原溶解的主要产物（X、Y、D和E）在原始纤维蛋白原分子中的位置相互关联起来。文中还讨论了由因子XIII不同程度交联的纤维蛋白裂解产物的复杂性。重点强调了交联纤维蛋白消化产物特有的两个片段（D二聚体和D二聚体-E复合物）的临床和结构意义。
