成人线状IgA大疱性皮肤病伴IgA和IgG沉积与大疱性类天疱疮的免疫电镜鉴别
Immunoelectronmicroscopic differentiation of linear IgA bullous dermatosis of adults with coexistence of IgA and IgG deposition from bullous pemphigoid.
作者信息
Adachi A, Tani M, Matsubayashi S, Shibata K, Horikawa T, Murata Y, Kumano K
机构信息
Department of Dermatology, Kobe University School of Medicine, Japan.
出版信息
J Am Acad Dermatol. 1992 Sep;27(3):394-9. doi: 10.1016/0190-9622(92)70205-t.
BACKGROUND
The differentiation between linear IgA bullous dermatosis (LABD) and bullous pemphigoid (BP) is sometimes difficult in patients who have both IgA and IgG deposition in a linear pattern at the basement membrane zone.
OBJECTIVE
We address whether two cases of acquired subepidermal blistering disease with coexistence of IgA and IgG deposition in a linear pattern at the basement membrane zone are LABD or BP.
METHODS
The two cases were investigated by immunoelectron microscopy and compared with two typical cases of LABD.
RESULTS
In both cases, the deposition of IgA and IgG was ultrastructurally localized below the lamina densa in close association with anchoring fibrils, as was seen in two cases of typical LABD.
CONCLUSION
These findings indicate that our two cases of acquired blistering disease with co-existence of IgA and IgG deposition are LABD, rather than BP.
背景
对于在基底膜带呈线性模式同时存在IgA和IgG沉积的患者，有时难以区分线性IgA大疱性皮肤病（LABD）和大疱性类天疱疮（BP）。
目的
我们探讨两例在基底膜带呈线性模式同时存在IgA和IgG沉积的获得性表皮下大疱性疾病是LABD还是BP。
方法
对这两例患者进行免疫电子显微镜检查，并与两例典型的LABD病例进行比较。
结果
在这两例病例中，IgA和IgG的沉积在超微结构上定位于致密板下方，与锚定原纤维紧密相关，这与两例典型的LABD病例所见相同。
结论
这些发现表明，我们的两例同时存在IgA和IgG沉积的获得性大疱性疾病病例是LABD，而非BP。
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