van Wyk C W, Thompson I O
Faculty of Dentistry, University of Stellenbosch, Tygerberg, S.A.
J Dent Assoc S Afr. 1992 May;47(5):234-6.
The aim of this study was to evaluate implanted ectocervical biopsy material as a model for morphological studies of normal and abnormal epithelial growth and epithelial-connective tissue interactions. Forty-five specimens were implanted in the flanks of nude (immunodeficient) mice and harvested at 1, 2, 3 and 6 weeks. Superficial necrosis of the epithelial layer with retention of parts of the basal cell layer were evident at 1 and 2 weeks. At 2 weeks granulation tissue enclosed the bases of the implants. Regrowth of epithelium on the surfaces and from the edges of the specimens was seen at 3 weeks. At 6 weeks the specimens were revascularized and the majority coated with a well developed unkeratinized stratified squamous epithelial layer resembling the epithelium of the ectocervix. It is concluded that specimens of human ectocervix, implanted in nude mice, offer the possibility for morphological studies of normal and abnormal epithelial growth and, if experimental difficulties can be overcome, of the epithelial-connective tissue interactions.
本研究的目的是评估植入的宫颈外活检材料，作为正常和异常上皮生长以及上皮-结缔组织相互作用形态学研究的模型。将45个标本植入裸（免疫缺陷）小鼠的胁腹，并在1、2、3和6周时收获。在1周和2周时，上皮层出现表面坏死，但部分基底细胞层保留。在2周时，肉芽组织包绕植入物的基部。在3周时，可见标本表面和边缘有上皮再生。在6周时，标本重新血管化，大多数表面覆盖着一层发育良好的未角化复层鳞状上皮，类似于宫颈外上皮。结论是，植入裸鼠的人宫颈外标本为正常和异常上皮生长的形态学研究提供了可能性，并且如果能够克服实验困难，也为上皮-结缔组织相互作用的研究提供了可能性。
