Thompson I O, van Wyk C W
Department of Oral Pathology, Faculty of Dentistry, University of Stellenbosch, South Africa.
Br J Oral Maxillofac Surg. 1996 Dec;34(6):530-2. doi: 10.1016/s0266-4356(96)90251-x.
Because of the scarcity of sizeable specimens of normal oral mucosa and the availability of human vaginal mucosa, which resembles the lining mucosa of the mouth, we used the latter to establish a human cyst model. Fragments of vaginal mucosa, removed during corrective procedures, were sutured around 2 mm glass balls and implanted into the flanks of nude mice. Thirty-seven specimens were implanted and 31 harvested after 3, 6, 9 and 12 weeks. At 6 weeks the wall of the implanted cyst consisted of recognizable unkeratinized vaginal mucosa but had not healed completely at the sutured edges. From 9 weeks the cyst cavities were healed and the lumens lined by unkeratinized stratified squamous vaginal epithelium. The enclosing connective tissue had retained the characteristics of the lamina propria of the vaginal mucosa and could be distinguished from mouse tissue.
由于正常口腔黏膜的大尺寸标本稀缺，且人类阴道黏膜与口腔内衬黏膜相似且易于获取，我们使用后者建立了人类囊肿模型。在矫正手术中切除的阴道黏膜碎片，围绕2毫米的玻璃球缝合后植入裸鼠的侧腹。共植入37个标本，在3周、6周、9周和12周后收获31个。6周时，植入囊肿的壁由可识别的未角化阴道黏膜组成，但缝合边缘尚未完全愈合。从9周开始，囊肿腔愈合，管腔由未角化的复层鳞状阴道上皮衬里。周围的结缔组织保留了阴道黏膜固有层的特征，可与小鼠组织区分开来。
