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脑脊液对离体维纳斯心脏的刺激和致敏作用。

Stimulation and sensitization of the isolated Venus heart by cerebrospinal fluid.

作者信息

BOWERS M B

出版信息

Br J Pharmacol Chemother. 1962 Oct;19(2):295-8. doi: 10.1111/j.1476-5381.1962.tb01191.x.

DOI:10.1111/j.1476-5381.1962.tb01191.x
PMID:14014616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1482137/
Abstract

5-Hydroxytryptamine was not detected in animal cerebrospinal fluid after amine oxidase inhibitors, reserpine, or both. Both human and animal cerebrospinal fluid can produce a stimulating effect on the clam heart which is not due to 5-hydroxytryptamine. Cerebrospinal fluid also has the property of increasing the sensitivity of the clam heart to 5-hydroxytryptamine.

摘要

在给予胺氧化酶抑制剂、利血平或两者后，动物脑脊液中未检测到5-羟色胺。人和动物的脑脊液均可对蛤蜊心脏产生刺激作用，这并非由5-羟色胺引起。脑脊液还具有增加蛤蜊心脏对5-羟色胺敏感性的特性。

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引用本文的文献

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Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1964 May 29;247:214-28. doi: 10.1007/BF00245965.

本文引用的文献

1
Accumulation of acetylcholine in brain and blood of animals poisoned with cholinesterase inhibitors.胆碱酯酶抑制剂中毒动物脑和血液中乙酰胆碱的蓄积。
Br J Pharmacol Chemother. 1952 Jun;7(2):270-6. doi: 10.1111/j.1476-5381.1952.tb01322.x.
2
Mytolon and related compounds as antagonists of acetylcholine on the heart of Venus mercenaria.米托隆及相关化合物作为乙酰胆碱对硬壳蛤心脏的拮抗剂。
J Pharmacol Exp Ther. 1952 Jun;105(2):232-9.
3
Exploration of the central nervous system serotonin in humans.
Ann N Y Acad Sci. 1962 Jan 13;96:108-17. doi: 10.1111/j.1749-6632.1962.tb50106.x.
4
Serotonin (5-hydroxytryptamine) and acetylcholine in human ventricular and spinal fluids.人体心室液和脊髓液中的血清素（5-羟色胺）与乙酰胆碱。
AMA Arch Gen Psychiatry. 1959 Dec;1:646-50. doi: 10.1001/archpsyc.1959.03590060108012.
5
Neurohumors and other pharmacologically active substances in cerebrospinal fluid: a review of the literature.脑脊液中的神经体液及其他药理活性物质：文献综述
Yale J Biol Med. 1960 Aug;33(1):15-36.
6
Pharmacological studies with the serotonin precursor, 5-hydroxytryptophan.使用血清素前体5-羟色氨酸的药理学研究。
J Pharmacol Exp Ther. 1958 Feb;122(2):182-94.
7
Some properties of the substance in human cerebrospinal fiuid sensitizing the frog rectus muscle to acetylcholine.人脑脊液中使蛙直肌对乙酰胆碱敏感的物质的某些特性。
J Physiol. 1957 Aug 6;137(3):460-72. doi: 10.1113/jphysiol.1957.sp005827.
8
Serotonin as a possible neurohumoral agent; evidence obtained in lower animals.血清素作为一种可能的神经体液介质；在低等动物身上获得的证据。
Ann N Y Acad Sci. 1957 Mar 14;66(3):618-30. doi: 10.1111/j.1749-6632.1957.tb40752.x.