Lindvall-Axelsson M, Mathew C, Nilsson C, Owman C
Department of Medical Cell Research, University of Lund, Sweden.
Exp Neurol. 1988 Feb;99(2):362-8. doi: 10.1016/0014-4886(88)90154-9.
Infusion of 5-hydroxytryptamine in mock cerebrospinal fluid of rabbits lowered cerebrospinal fluid production dose-dependently by nearly 30%. The effect was amplified in the presence of the monoamine oxidase inhibitor, nialamide. The 5-hydroxytryptamine-induced inhibition was partly counteracted by ketanserin, and further addition of practolol completely blocked the reduction in cerebrospinal fluid formation, suggesting that both 5-hydroxytryptamine receptors and beta 1-adrenergic receptors were involved in the response mediated by both the secretory epithelium and the vascular bed of the plexus.
向兔模拟脑脊液中输注5-羟色胺可使脑脊液生成量剂量依赖性降低近30%。在单胺氧化酶抑制剂尼亚酰胺存在的情况下，这种作用会增强。5-羟色胺诱导的抑制作用部分被酮色林抵消，进一步添加心得宁则完全阻断了脑脊液生成的减少，这表明5-羟色胺受体和β1-肾上腺素能受体均参与了由丛的分泌上皮和血管床介导的反应。
