再生障碍性贫血患者泌尿生殖区域的三重癌症。

Triple cancers in the urogenital area of a patient with aplastic anemia.

作者信息

Sato K C, Furuta Y, Takasu T, Nagashima K, Fukaya T, Koizumi H, Ohkawara A, Yamashiro K, Kawashima K, Yoshida T

机构信息

Hokkaido University School of Medicine, Department of Dermatology, Sapporo, Japan.

出版信息

J Dermatol. 1992 Jun;19(6):362-8. doi: 10.1111/j.1346-8138.1992.tb03240.x.

DOI:10.1111/j.1346-8138.1992.tb03240.x

PMID:1401490

Abstract

Three epithelial neoplastic lesions, perineal Bowenoid papulosis, uterine cervical carcinoma, and bladder transitional cell carcinoma, which occurred in a mildly immunosuppressed patient who had aplastic anemia were studied for human papillomavirus (HPV) infection. In the Bowenoid papulosis, HPV type 16 DNA was identified by polymerase chain reaction (PCR) and by in situ hybridization (ISH). In contrast, in the uterine cervical carcinoma, HPV 16 was not detected, although possibly another unidentified type of HPV in the lesion was suggested by the ISH findings. In the bladder transitional cell carcinoma, neither papillomavirus genus-specific (PGS) antigen nor HPV DNA was found.

摘要

对一名患有再生障碍性贫血且轻度免疫抑制的患者所发生的三种上皮性肿瘤病变，即会阴鲍温样丘疹病、子宫颈癌和膀胱移行细胞癌，进行了人乳头瘤病毒（HPV）感染研究。在鲍温样丘疹病中，通过聚合酶链反应（PCR）和原位杂交（ISH）鉴定出16型HPV DNA。相比之下，在子宫颈癌中，未检测到HPV 16，尽管ISH结果提示病变中可能存在另一种未鉴定的HPV类型。在膀胱移行细胞癌中，未发现乳头瘤病毒属特异性（PGS）抗原和HPV DNA。