丁基羟基茴香醚对紫外线B和补骨脂素加长波紫外线诱导的小鼠皮肤鸟氨酸脱羧酶活性的影响。

Effects of butylated hydroxyanisole on ornithine decarboxylase activity induced by ultraviolet-B and PUVA in mouse skin.

作者信息

Kono T, Taniguchi S, Mizuno N, Fukuda M, Maekawa N, Hisa T, Ishii M, Otani S, Hamada T

机构信息

Department of Dermatology, Osaka City University Medical School, Japan.

出版信息

J Dermatol. 1992 Jul;19(7):389-92. doi: 10.1111/j.1346-8138.1992.tb03246.x.

DOI:10.1111/j.1346-8138.1992.tb03246.x

PMID:1401495

Abstract

The effects of butylated hydroxyanisole (BHA), a representative phenolic antioxidant, on the activity of ornithine decarboxylase (ODC, an indicator of tumor promotion and epidermal hyperproliferation) induced by ultraviolet-B (UVB) or PUVA in mouse skin were investigated. By topical application of BHA (55 mumol), PUVA-induced ODC activity was suppressed by about 60% at both 12 h and 24 h after treatment. In contrast, BHA failed to suppress UVB-induced ODC activity in mouse skin. These results suggest that the induction of ODC activity by UVB or PUVA is mediated by different pathways.

摘要

研究了代表性酚类抗氧化剂丁基羟基茴香醚（BHA）对紫外线B（UVB）或补骨脂素加紫外线A（PUVA）诱导的小鼠皮肤鸟氨酸脱羧酶（ODC，肿瘤促进和表皮过度增殖的指标）活性的影响。通过局部应用BHA（55微摩尔），在治疗后12小时和24小时，PUVA诱导的ODC活性均被抑制约60%。相比之下，BHA未能抑制小鼠皮肤中UVB诱导的ODC活性。这些结果表明，UVB或PUVA诱导的ODC活性是由不同途径介导的。