Barberger-Gateau P, Commenges D, Gagnon M, Letenneur L, Sauvel C, Dartigues J F
INSERM U.330, Université de Bordeaux II, France.
J Am Geriatr Soc. 1992 Nov;40(11):1129-34. doi: 10.1111/j.1532-5415.1992.tb01802.x.
To identify which Instrumental Activities of Daily Living (IADL) are related to cognitive impairment, independent of age, sex, and education; to assess the performance of an IADL score using these items in screening for cognitive impairment and dementia in elderly community dwellers.
Survey based on the baseline interview of the PAQUID study on functional and cerebral aging.
Community survey in 37 randomly selected parishes in Gironde, France.
Random sample of 2,792 community dwellers aged 65 and over (participation rate: 69%).
Two-phase screening: (1) functional assessment, Mini-Mental State Examination (MMSE) and DSM-III criteria for dementia; (2) in DSM-III-positive patients, NINCDS-ADRDA criteria applied by a neurologist. Functional assessment: IADL scale of Lawton and Brody. Criterion standards: cognitive impairment: MMSE score lower than 24; dementia: DSM-III and NINCDS-ADRDA criteria.
Four IADL items are correlated with cognitive impairment independent of age, sex, and education: telephone use, use of means of transportation, responsibility for medication intake, and handling finances. A score adding the number of IADL dependencies has a sensitivity of 0.62 and a specificity of 0.80 at the lowest cut-off point (score > 0) for the diagnosis of cognitive impairment. The same score at the same cut-off has a sensitivity of 0.94 and a specificity of 0.71 for the diagnosis of dementia. The prevalence of dementia (2.4%) is reduced by a factor of 12 in subjects independent for the four IADL.
The four IADL score could be incorporated into the screening procedure for dementia in elderly community dwellers.
确定哪些日常生活工具性活动(IADL)与认知障碍相关,且不受年龄、性别和教育程度的影响;评估使用这些项目的IADL评分在筛查老年社区居民认知障碍和痴呆症方面的表现。
基于PAQUID关于功能和脑老化研究的基线访谈进行的调查。
法国吉伦特省37个随机选取教区的社区调查。
2792名65岁及以上社区居民的随机样本(参与率:69%)。
两阶段筛查:(1)功能评估、简易精神状态检查表(MMSE)和痴呆症的DSM-III标准;(2)在DSM-III阳性患者中,由神经科医生应用NINCDS-ADRDA标准。功能评估:Lawton和Brody的IADL量表。标准:认知障碍:MMSE评分低于24;痴呆症:DSM-III和NINCDS-ADRDA标准。
四个IADL项目与认知障碍相关,且不受年龄、性别和教育程度的影响:电话使用、交通工具使用、药物服用责任和财务管理。将IADL依赖项数量相加得出的评分,在诊断认知障碍的最低临界值(评分>0)时,灵敏度为0.62,特异度为0.80。在相同临界值下,该评分诊断痴呆症的灵敏度为0.94,特异度为0.71。在四个IADL项目均独立的受试者中,痴呆症患病率(2.4%)降低了12倍。
四个IADL评分可纳入老年社区居民痴呆症的筛查程序。