Loche S, Balzano S, Bozzola M, Moretta A, Pintus S, Faedda A, Muntoni A, Carta D, Pintor C
Istituto di Clinica Pediatrica, Università di Cagliari, Italy.
J Endocrinol Invest. 1992 Jun;15(6):453-7. doi: 10.1007/BF03348770.
We have evaluated baseline and l-dopa-stimulated peripheral growth hormone releasing hormone (pGHRH) secretion in 6 obese pre-pubertal children and in 7 age-matched controls. Baseline pGHRH levels were no different between obese (36.6 +/- 9.8 pg/ml, mean +/- SE) and control children (40.6 +/- 10.1 pg/ml). Administration of l-dopa (500 mg po) caused a significant increase of pGHRH levels in both the obese (65.3 +/- 19.8 pg/ml, p less than 0.05) and the control children (84.1 +/- 10.0 pg/ml, p less than 0.003). Mean peak pGHRH levels after l-dopa were not significantly different between the two groups, whereas mean peak GH levels were significantly lower (p less than 0.05) in the obese (7.9 +/- 1.9 ng/ml) than in the control children (20.5 +/- 4.9 ng/ml). We conclude that despite reduced GH secretion, obese children have normal baseline and l-dopa stimulated pGHRH levels.
我们评估了6名肥胖青春期前儿童和7名年龄匹配的对照儿童的基础状态及左旋多巴刺激后的外周生长激素释放激素（pGHRH）分泌情况。肥胖儿童（36.6±9.8 pg/ml，均值±标准误）和对照儿童（40.6±10.1 pg/ml）的基础pGHRH水平无差异。给予左旋多巴（口服500 mg）后，肥胖儿童（65.3±19.8 pg/ml，p<0.05）和对照儿童（84.1±10.0 pg/ml，p<0.003）的pGHRH水平均显著升高。两组左旋多巴刺激后的pGHRH平均峰值水平无显著差异，而肥胖儿童（7.9±1.9 ng/ml）的生长激素（GH）平均峰值水平显著低于对照儿童（20.5±4.9 ng/ml）（p<0.05）。我们得出结论，尽管肥胖儿童的GH分泌减少，但其基础状态及左旋多巴刺激后的pGHRH水平正常。
