Johnson K J, Anderson T P, Ward P A
J Clin Invest. 1977 May;59(5):951-8. doi: 10.1172/JCI108717.
Small amounts (10(-10) mol) of purified human chemotactic factor inactivator (CFI) suppress leukocytic infiltration, permeability changes, and hemorrhage associated with acute immune complex-induced injury in rats. The reversed passive dermal Arthus reaction and acute immune complex-induced alveolitis in rats have served as the model systems of inflammation. The mechanism of inhibition does not appear to relate to interference with formation and deposition of immune complexes, or with fixation of complement in vitro or iv vivo. Human CFI inhibits in vitro the chemotactic activity generated in complement-activated rat serum. The inhibitory effects of human CFI are not seen if it is first heat inactivated. The data provide the first direct support for the conclusion that CFI has anti-inflammatory activity.
少量（10⁻¹⁰摩尔）纯化的人趋化因子灭活剂（CFI）可抑制与大鼠急性免疫复合物诱导损伤相关的白细胞浸润、通透性变化和出血。大鼠的反向被动皮肤Arthus反应和急性免疫复合物诱导的肺泡炎已作为炎症的模型系统。抑制机制似乎与干扰免疫复合物的形成和沉积，或体外或体内补体的固定无关。人CFI在体外抑制补体激活的大鼠血清中产生的趋化活性。如果人CFI先经热灭活，则看不到其抑制作用。这些数据为CFI具有抗炎活性这一结论提供了首个直接支持。
