Tyagi S P, Tyagi N, Maheshwari V, Ashraf S M, Sahoo P
Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University.
J Indian Med Assoc. 1992 Jul;90(7):178-81.
Morphological changes of gall bladder were studied in 415 cholecystectomy specimens. There was a preponderance of females (male to female ratio--1:6.5). The mean age of the cases was 43.6 years. Most of the cases (63.4%) were in the 4th and 5th decades of life. The average duration of illness was 2.8 years. Associated cholelithiasis was present in 85.3% cases. Gall-stones were of mixed variety in 78.2% cases, cholesterol type in 15.3% cases and both types were present in 6.5% cases. Chronic cholecystitis was the main histological diagnosis (50.8%). Other lesions observed were adenomyomatosis (8.2%), adenomatous hyperplasia (10.1%), granulomatous cholecystitis (4.1%), cholesterosis (2.7%), acute cholecystitis (4.1%), acute on chronic infection (10.8%), sub-acute cholecystitis (2.4%) and carcinoma gall bladder (6.8%). The frequency of Rokitansky-Aschoff's sinuses was closely related with the degree of inflammatory response. In 13 (6.2%) cases the diagnosis of chronic follicular cholecystitis was made. All the cases of cholesterosis were multiparous females and of younger age. Of the malignant lesions, adenocarcinoma was the commonest (96.4%).
对415例胆囊切除术标本的胆囊形态学变化进行了研究。女性占多数（男女比例为1:6.5）。病例的平均年龄为43.6岁。大多数病例（63.4%）处于40至59岁年龄段。平均病程为2.8年。85.3%的病例伴有胆石症。78.2%的病例胆石为混合型，15.3%的病例为胆固醇型，6.5%的病例两种类型均有。慢性胆囊炎是主要的组织学诊断（50.8%）。观察到的其他病变有腺肌瘤病（8.2%）、腺瘤样增生（10.1%）、肉芽肿性胆囊炎（4.1%）、胆固醇沉着症（2.7%）、急性胆囊炎（4.1%）、慢性感染急性发作（10.8%）、亚急性胆囊炎（2.4%）和胆囊癌（6.8%）。罗-阿窦的发生率与炎症反应程度密切相关。13例（6.2%）诊断为慢性滤泡性胆囊炎。所有胆固醇沉着症病例均为经产妇且年龄较轻。在恶性病变中，腺癌最为常见（96.4%）。
