Lehmann L, Kraus K
Zentralbl Chir. 1976;101(14):848-54.
741 cholecystektomies were examined for cholesterosis. In 92% gallstones were present and in 8% there were no stones. Cholesterosis of the gallbladder was found in 0,9% of 4417 autopsies. It was combined with gallstones in 25% and in 75% it was not. There was no difference concerning the clinical symptoms between cholesterosis with and without stones in the surgical patients. Cholesterosis without stone presented the same picture as gallstones. In the autopsy material however no typical symptoms could be found indicating either cholesterosis with gallstones or without. In the histological examination 80,5% of the cases with gallstones in the surgical and autopsy group had inflammatory changes of the gallbladder wall whereas only 22% of the cases with stoneless cholesterosis showed these alterations. Fibrosis of the gallbladder wall however was found in 86,1% in cases with cholesterosis without stones and in 88% in cases with stones. From these findings the conclusion is made that cholesterosis is no well defined disease. Clinical symptoms seem to appear only when other factors, such as stones, inflammation or functional disturbances probably because of fibrosis of the wall, become manifest in addition.
对741例胆囊切除术患者进行了胆固醇沉着症检查。其中92%存在胆结石，8%无结石。在4417例尸检中，胆囊胆固醇沉着症的发生率为0.9%。它与胆结石合并存在的占25%，不合并的占75%。手术患者中，有结石和无结石的胆固醇沉着症在临床症状方面没有差异。无结石的胆固醇沉着症表现与胆结石相同。然而，在尸检材料中，未发现表明有结石或无结石的胆固醇沉着症的典型症状。组织学检查显示，手术组和尸检组中有胆结石的病例中，80.5%的胆囊壁有炎症改变，而无结石的胆固醇沉着症病例中只有22%有这些改变。然而，无结石的胆固醇沉着症病例中胆囊壁纤维化的发生率为86.1%，有结石的病例中为88%。从这些发现得出的结论是，胆固醇沉着症不是一种定义明确的疾病。临床症状似乎只有在出现其他因素时才会出现，如结石、炎症或可能由于胆囊壁纤维化导致的功能障碍。
