Hochstrasser K, Niebel J, Feuth H, Lempart K
Klin Wochenschr. 1977 Apr 1;55(7):337-42. doi: 10.1007/BF01488112.
The humoral inter-alpha-trypsin inhibitor is to define as precursor of the acid stable trypsin-plasmin-inhibitor in the serum. The inhibitor is filtrated by the glomerulum and excreted in the urine. The serum level of the inhibitor is increased in nephropathy. Using a new assay for the intact precursor it was found that during inflammation the decreased precursor level indicates an increased turnover, though the glomerular filtration of the acid-stable inhibitor is within normal range. The increase of the precursor level during nephropathy indicates that the kidney is the main degradation organe for the inter-alpha-trypsin inhibitor. Nevertheless, an increase of the acid-stable inhibitor is to be seen. This fact is only to explain if it is assumed that the inter-alpha-trypsin inhibitor is permanently degraded everywhere in the organism.
体液中的α-胰蛋白酶抑制剂被定义为血清中酸稳定的胰蛋白酶-纤溶酶抑制剂的前体。该抑制剂经肾小球滤过并随尿液排出。在肾病中，该抑制剂的血清水平会升高。使用一种针对完整前体的新检测方法发现，在炎症期间，前体水平降低表明其周转率增加，尽管酸稳定抑制剂的肾小球滤过在正常范围内。肾病期间前体水平的升高表明肾脏是α-胰蛋白酶抑制剂的主要降解器官。然而，仍可观察到酸稳定抑制剂的增加。只有假设α-胰蛋白酶抑制剂在机体各处持续降解，才能解释这一事实。
