Hamilton-Miller J M, Maple P A
Department of Medical Microbiology, Royal Free Hospital School of Medicine, London, UK.
J Chemother. 1992 Feb;4(1):6-8. doi: 10.1080/1120009x.1992.11739129.
Rokitamycin was more active than erythromycin against erythromycin-sensitive strains of Staphylococcus aureus and enterococci, but somewhat less active against coagulase-negative staphylococci. Strains with inducible resistance to erythromycin were uniformly resistant to erythromycin, while rokitamycin was active against such strains. Strains with constitutive resistance to erythromycin were also uniformly resistant to erythromycin, and most were also resistant to rokitamycin. However, 5 of 21 coagulase-negative staphylococci and 2 of 20 enterococci remained sensitive to rokitamycin. This is a novel finding, perhaps suggesting a new mechanism of macrolide resistance.
罗他霉素对红霉素敏感的金黄色葡萄球菌和肠球菌菌株的活性比红霉素更强，但对凝固酶阴性葡萄球菌的活性略低。对红霉素具有诱导性耐药的菌株对红霉素均耐药，而罗他霉素对此类菌株有活性。对红霉素具有组成性耐药的菌株对红霉素也均耐药，且大多数对罗他霉素也耐药。然而，21株凝固酶阴性葡萄球菌中有5株以及20株肠球菌中有2株对罗他霉素仍敏感。这是一个新发现，可能提示了大环内酯类耐药的一种新机制。
