Ryser J E, Jones R M, Egeli R, Pélegrin A, Rose K, Kurt A M, Perin M, Broquet P E, Ambrosetti P, Fisch I
Division de Médecine Nucléaire, Hôpital Cantonal Universitaire, Geneva, Switzerland.
J Nucl Med. 1992 Oct;33(10):1766-73.
Previous experimental results in nude mice showing that radiolabeling the monoclonal antibody anti-CEA 35 with 67Ga-aminooxyacetyldeferroxamine could give better tumor localization than radioiodination prompted us to initiate the present clinical study. The 67Ga-labeled antibody anti-CEA 35 (185 MBq, 0.7-1.7 mg) was injected preoperatively into 14 patients for colorectal carcinoma imaging. The same antibody labeled with 125I (3.7 MBq, 0.25 mg) was injected simultaneously to compare the 67Ga and 125I dose recoveries in surgical specimens. Twelve of 14 primary tumors gave a positive 67Ga scintigraph. The mean %ID/g recovered in all tumors 3-9 days after injection was significantly higher for 67Ga (0.019%) than for 125I (0.005%) (p < 0.001, paired t test). The tumor-to-normal tissue ratios were generally higher for 67Ga, with the exception of liver. We conclude that 67Ga-aminooxyacetyldeferroxamine improved immunoscintigraphy outside the liver, particularly in the pelvic region. We also show that deferroxamine infusion accelerates the excretion of 67Ga in eight patients and propose that this could lead to further improvement of immunoscintigraphy.
先前在裸鼠身上进行的实验结果表明，用67Ga-氨氧基乙酰去铁胺对单克隆抗体抗CEA 35进行放射性标记，与放射性碘化相比，能实现更好的肿瘤定位，这促使我们开展本临床研究。术前将67Ga标记的抗CEA 35抗体（185 MBq，0.7 - 1.7 mg）注射到14例结直肠癌患者体内进行成像。同时注射相同剂量的125I标记抗体（3.7 MBq，0.25 mg），以比较手术标本中67Ga和125I的剂量回收率。14例原发性肿瘤中有12例67Ga闪烁扫描呈阳性。注射后3 - 9天，所有肿瘤中67Ga的平均%ID/g回收率（0.019%）显著高于125I（0.005%）（p < 0.001，配对t检验）。除肝脏外，67Ga的肿瘤与正常组织比值通常更高。我们得出结论，67Ga-氨氧基乙酰去铁胺改善了肝脏外的免疫闪烁显像，尤其是在盆腔区域。我们还发现，去铁胺输注可加速8例患者体内67Ga的排泄，并提出这可能会进一步改善免疫闪烁显像。
