Williams L E, Bares R B, Fass J, Hauptmann S, Schumpelick V, Buell U
Division of Radiology, City of Hope National Medical Center, Duarte, CA 91010.
Eur J Nucl Med. 1993 Apr;20(4):345-7. doi: 10.1007/BF00169812.
An inverse correlation has been demonstrated between tumor uptake (u, in units of % injected dose/kg) of monoclonal antibody (Mab) and tumor mass (m, in units of g) for colorectal carcinoma in a series of 19 consecutive patients. The correlation (rho = -0.510), developed using surgical samples was of the form u = amb and was significant at the 2% level of confidence. All tumors were positive for carcinoembryonic antigen (CEA) and the radiopharmaceutical was an iodine-131 labeled anti-CEA Mab. Such correlations have been predicted earlier from murine and rat tumor uptake data. The slope parameter (b) was -0.362, a number consistent with the previous value (-0.382) found in anti-CEA experiments in mice bearing human xenograft LS174T tumors.
在连续19例结直肠癌患者中，已证明单克隆抗体（Mab）的肿瘤摄取量（u，单位为%注射剂量/千克）与肿瘤质量（m，单位为克）之间存在负相关。使用手术样本得出的相关性（rho = -0.510）形式为u = amb，在2%的置信水平上具有显著性。所有肿瘤的癌胚抗原（CEA）均呈阳性，放射性药物为碘-131标记的抗CEA Mab。这种相关性早些时候已从小鼠和大鼠肿瘤摄取数据中预测出来。斜率参数（b）为-0.362，这一数值与在携带人异种移植LS174T肿瘤的小鼠中进行的抗CEA实验中先前发现的值（-0.382）一致。
